Results 31 to 40 of about 1,288,161 (236)
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Debating Democracy: Concepts, Histories, and Controversies
Politics and GovernanceWithin academia as much as in political practice, democracy remains a contested concept. This issue focuses on the practices of the contestation of the concept of democracy—the debates, controversies, and contestations of democracy in theory, practice ...
Claudia Wiesner, Kari Palonen
doaj +1 more source
Systematic Analysis of State-Nation Building and Political Development in Afghanistan: A Critical Approach to the Bonn Agreement and the Doctrine of Liberal Democracy from 2002 to 2021 [PDF]
Journal of World Sociopolitical Studies, 2020 By withdrawing from Afghanistan, the Soviet Union collapsed and the Cold War ended in the 1990s. Throughout that decade, western governments forgot the people of Afghanistan.
Rohollah Eslami, Ebrahim Forozesh
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Appealing. The Biden Doctrine in the “Cold Democracy” Age
Diversitas Journal, 2022 Western democracies have lost their compass. They are cold and with no appeal; not looked upon as an efficient and effective model of governance. The Biden Doctrine might be defined as Joe Biden’s worldview divided between democracy and authoritarianism,
Amedeo Gasparini
doaj +1 more source
, 2020 This open access book aims to show which factors have been decisive in the rise of successful countries. Never before have so many people been so well off. However, prosperity is not a law of nature; it has to be worked for. A liberal economy stands at the forefront of this success – not as a political system, but as a set of economic rules promoting ...
openaire +3 more sources
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Ethical Foreground and Background in Adult Educator Work
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley +1 more source
The Fragility of Liberal Democracy Faced with Fascism and Climate Politics
AthenaThis article engages with the particular fragility of liberal democracy in current times. The particularity at stake here concerns the two major challenges that liberal democracy faces today, notably the rising allure of fascism (mostly AF hereafter) and
Johan Van der Walt
doaj +1 more source