Results 141 to 150 of about 4,394,525 (348)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

IMPROVEMENT OF LIBRARY AND LIBRARY MAINTENANCE IN THE LIBRARY OF THE UNIVERSITY

open access: yesEducational Dimension, 2008
Modern forms and methods of library-bibliographic service in the university library are being considered, the impontance of computerizing of libraries is stressed.
openaire   +2 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

From the Lab to Librarianship: Advancing Open Science

open access: yesIssues in Science and Technology Librarianship
Three library professionals share their perspectives on transitioning from STEM research to librarianship. A STEM PhD or postdoctoral researcher can bring technical expertise and a deep understanding of researcher culture to library services and at the ...
Melanie A. Gainey   +2 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

LibQUAL+ 2007 Survey Memorial University of Newfoundland [Canada]

open access: yes, 2007
The LibQUAL+ survey was conducted by Memorial University of Newfoundland Libraries from March 12th through April 9th, 2007 to assess user perceptions of how well the libraries are meeting the needs of students, faculty and staff.
Association of Research Libraries
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

LibQUAL+ 2005 Survey Memorial University of Newfoundland [Canada]

open access: yes, 2005
The LibQUAL+ survey was conducted for the first time by Memorial University of Newfoundland Libraries during March and April 2005 to assess user perceptions of how well the libraries are meeting the needs of students, faculty and staff.
Association of Research Libraries
core  

Public Libraries, Children and Young People and Social Exclusion [PDF]

open access: yes, 2000
The paper begins by considering the dimensions of the social exclusion of children and young people, including poverty and its relationship with exclusion from school. It then reviews central initiatives in the area of children’s literacy. The paper then
Vincent, John
core  

The Library in the Liturgy. The Liturgy in the Library

open access: yes, 2020
The study of physical location of liturgical books constitutes a particularly fruitful means of investigating the implications of de-contextualization and re-contextualization of book objects. Not only do the numbers, types, and ever-evolving combinations of liturgical books as single-volume pluritextual libraries present considerable challenges for ...
openaire   +1 more source

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