Results 41 to 50 of about 2,104,703 (305)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Ljubljana University Library: from the collaps of fascist Italy to the end of the second World War (1943-1945)

open access: yesKnjižnica, 2005
The Library of the University in Ljubljana moved into the new library building in 1941 at the very beginning of the Second World War. By 1943, when fascist Italy collapsed, the building was almost completely furnished.
Eva Kodrič-Dačić
doaj   +1 more source

EbbRT: a framework for building per-application library operating systems [PDF]

open access: yes, 2016
Efficient use of high speed hardware requires operating system components be customized to the application work- load. Our general purpose operating systems are ill-suited for this task.
Appavoo, Jonathan   +4 more
core   +1 more source

Marketing library services to children and young people [PDF]

open access: yes, 2006
This paper discusses the future of Schools Library Services in the North West region of England based on a research project recently undertaken by the Centre for the Public Library and Information in Society at the University of Sheffield on behalf of ...
Train, B., Wilson, K.
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Workshop - Building great libraries: What makes a library building successful?

open access: yes, 2022
The LIBER Architecture Group organized a workshop on library buildings, library design, and how we judge the success of a library. The workshop was done with the help of the ‘Library buildings in Europe’ Database (https://www.librarybuildings.eu), allowing workshop participants to get hands-on information on library design and architecture.
Moennich, Michael   +3 more
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Identifying eighteenth century pigments at the Bodleian library using in situ Raman spectroscopy, XRF and hyperspectral imaging

open access: yesHeritage Science, 2017
There are multiple challenges in analysing pigments in historic watercolour paintings on paper, and typically non-invasive, in situ methods are required.
R. Mulholland   +4 more
doaj   +1 more source

University College London: Library DDA works PPG15 justification. Conservation strategy report. [PDF]

open access: yes, 2004
Introduction: This report has been prepared for the Estates and Facilities Division of University College London (UCL). UCL needs to make alterations to the Wilkins building to improve access to the library (on its upper floors) by the end of the year
Filmer-Sankey, W., Markham, L.
core  

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