Results 61 to 70 of about 1,348,933 (298)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

DESCRIPTION OF CLASSIFICATION SYSTEMS OF LIBRARY CATALOGUES

open access: yesІнформаційні технології і засоби навчання, 2010
The description of the most widespread universal library classifications (Decimal Classification of D'yui (DKD), Universal Decimal Classification (UDK), Classification of Library of Congress (KBK), Library-Bibliographic Classification (BBK)) are analysed
Zoya V. Savchenko
doaj  

The Once and Future Library

open access: yesIssues in Science and Technology Librarianship, 1996
In Fall 1995, a World Wide Web (WWW) virtual library was established to investigate the applicability of using a conventional library classification scheme as an organizational framework for enhancing identification, access and use of Internet resources
Gerry McKiernan
doaj   +1 more source

A Digital Low Dispersion Spectral Library Covering the 3500-7500AA Region Using the SAAO Radcliffe 1.9m Telescope's Cassegrain Spectrograph

open access: yes, 2013
We have created a digital spectral library, using low resolution optical spectra, of photometric and spectral standard stars. The data were acquired using the Cassegrain Spectrograph installed on the 1.9m Radcliffe telescope at the South African ...
James, David
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Using IODyne: Illustrations and Examples [PDF]

open access: yes, 1998
"IODyne (pronounced ""iodine"") is an Internet client program that allows one to retrieve information from servers by dynamically combining information objects.
Johnson, Eric H.
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Prolegomena to Library Classification

open access: yes, 1937
The First Part expounds the theory of classification. After the first seven pages, the first chap­ter, which seeks to build up the necessary scaffolding of terminology, may prove to be stiff reading for beginners. But they may skip over that portion in the first reading and refer to it whenever need is felt for definition of technical terms. The second
openaire   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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