Results 41 to 50 of about 324,512 (267)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Covering the Feminine Form in the Osler Library of the History of Medicine
Acta Universitatis Lodziensis: Folia Litteraria RomanicaTo William Osler, a firm grasp of the history of medicine was integral to the formation of a good doctor. This conviction drove his decision to amass a history of medicine library for the McGill Medical Faculty.
Mary Hague-Yearl
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Literacy Development: Unveiling the Role of Balai Poestaka: A Historical Study
Khizanah al-Hikmah, 2023 The existence of Balai Poestaka was aimed to facilitate the Dutch East Indies Government in monitoring the circulation of "appropriate reading materials for the people." Therefore, on September 14, 1908, the Commissie voor de Inlandsche School en ...
Nurmalina, Romli SA., Endang Rochmiatun
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2021 Objectives: this study analyses the provenance of the collection acquired by Eduard Toda in England which was then housed in his residence in the Escornalbou Castle-Monastery.
Pedro José Rueda Ramírez +1 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Digitalisierung am Deutschen Museum – alles andere als retro
Library Ideas, 2021 Die Digitalisierung und Onlinepräsentation von Buchbeständen ist in der Welt der Bibliotheken schon lange kein Novum mehr. Der Artikel beschreibt am Beispiel der Projekte der Bibliothek des Deutschen Museums die verschiedenen Formen von ...
Christian Winkler
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source