Results 41 to 50 of about 31,361,972 (278)
Social and Developmental Consequences of Reza Shah’s Expansion of Private Estates in Kermanshah [PDF]
The seizure of agricultural lands and the dispossession of ruling-class owners by new authorities has a long history in Iran, serving as an institutionalized method for gaining power and weakening previous dynasties.
Motaleb Motalebi, Shahram Gholami
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The article presents the first results of a research about the library of the Jesuit Cardinal Roberto Bellarmino (1542-1621). The starting point are some unpublished works dedicated to this topic compiled by two Jesuit scholars in the first half of ‘ 900:
Lorenzo Mancini
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Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Feoktist Ulegov, author of “The Guest Court of Russian Literature” [PDF]
The article introduces the biography and characterizes works of Feoktist Andreevich Ulegov (1803–1830), the former serf of Ural manufacturers Demidovs.
Abram I. Reitblat, Vladimir A. Shkerin
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Objectives: this study analyses the provenance of the collection acquired by Eduard Toda in England which was then housed in his residence in the Escornalbou Castle-Monastery.
Pedro José Rueda Ramírez +1 more
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Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
1525. aasta Liivimaa keeltes trükised Euroopa raamatuloolisel taustal [PDF]
In 1525, a barrel containing Lutheran books was confiscated in Lübeck. According to the chapter register (Actus capitulares) of Johannes Brandes, dean of the cathedral chapter of Lübeck, the shipment included masses in Estonian, Latvian and possibly ...
Kaspar Kolk
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source

