Results 41 to 50 of about 31,361,972 (278)

Social and Developmental Consequences of Reza Shah’s Expansion of Private Estates in Kermanshah [PDF]

open access: yesپژوهش های تاریخی
The seizure of agricultural lands and the dispossession of ruling-class owners by new authorities has a long history in Iran, serving as an institutionalized method for gaining power and weakening previous dynasties.
Motaleb Motalebi, Shahram Gholami
doaj   +1 more source

«Piccola, ma sufficiente per li miei studi»: the library of Cardinal Roberto Bellarmino. First investigations and census of annotated books

open access: yesBibliothecae.it, 2021
The article presents the first results of a research about the library of the Jesuit Cardinal Roberto Bellarmino (1542-1621). The starting point are some unpublished works dedicated to this topic compiled by two Jesuit scholars in the first half of ‘ 900:
Lorenzo Mancini
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Feoktist Ulegov, author of “The Guest Court of Russian Literature” [PDF]

open access: yesЛитературный факт, 2018
The article introduces the biography and characterizes works of Feoktist Andreevich Ulegov (1803–1830), the former serf of Ural manufacturers Demidovs.
Abram I. Reitblat, Vladimir A. Shkerin
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Procedències dels impresos de la biblioteca del Castell Monestir d'Escornalbou : les marques de propietat de la col·lecció d'Eduard Toda

open access: yesBiD: Textos Universitaris de Biblioteconomia i Documentació, 2021
Objectives: this study analyses the provenance of the collection acquired by Eduard Toda in England which was then housed in his residence in the Escornalbou Castle-Monastery.
Pedro José Rueda Ramírez   +1 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

1525. aasta Liivimaa keeltes trükised Euroopa raamatuloolisel taustal [PDF]

open access: yesMäetagused
In 1525, a barrel containing Lutheran books was confiscated in Lübeck. According to the chapter register (Actus capitulares) of Johannes Brandes, dean of the cathedral chapter of Lübeck, the shipment included masses in Estonian, Latvian and possibly ...
Kaspar Kolk
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

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