Results 241 to 250 of about 1,508,332 (327)

Direct-to-Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery. [PDF]

ChemMedChem
Hübner AF, Barthels F.
europepmc   +1 more source

Bioinspired Stabilization of Fluorescent Au@SiO2 Tracers for Multimodal Biological Imaging

Advanced Functional Materials, EarlyView.
This study demonstrates a bioinspired stabilization strategy for fluorescent gold‐silica nanoparticles. Inspired by natural biosilica maturation, high‐temperature calcination transforms the silica shells, preventing dissolution in cell culture media and intracellular environments.
Wang Sik Lee, Henry Lee, Patricia Taladriz‐Blanco, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Alke Petri‐Fink   +5 more
wiley   +1 more source

Pleiotropic mutational effects on function and stability constrain the antigenic evolution of influenza haemagglutinin. [PDF]

Nat Ecol Evol
Yu TC, Kikawa C, Dadonaite B, Loes AN, Englund JA, Bloom JD.   +5 more
europepmc   +1 more source

A study of Reference Model of Smart Library based on Linked Open Data

, 2016
Heekyung Moon, Sung‐Kook Han
openalex   +1 more source

From Wafers to Electrodes: Transferring Automatic Optical Inspection (AOI) for Multiscale Characterization of Smart Battery Manufacturing

Advanced Functional Materials, EarlyView.
Automat optical inspection (AOI) techniques in semiconductor fabrication can be leveraged in battery manufacturing, enabling scalable detection and analysis of electrode‐ and cell‐level imperfections through AI‐driven analytics and a digital‐twin framework.
Jianyu Li, Ertao Hu, Wei Wei, Feifei Shi
wiley   +1 more source

<i>Alpseq</i>: an open-source workflow to turbocharge nanobody discovery with high-throughput sequencing. [PDF]

MAbs
Zeglinski K, Schuster J, Sa JD, Adair A, Deng J, Pymm P, Ritchie ME, Bowden R, Tham WH, Gouil Q.   +9 more
europepmc   +1 more source

Widespread false negatives in DNA-encoded library data: how linker effects impair machine learning-based lead prediction

Alba L. Montoya, Adam S. Hogendorf, Scott Tingey, Aadarsh Kuberan, Lik Hang Yuen, H. Schüler, Raphael M. Franzini   +6 more
openalex   +2 more sources

Mechanoregulatory Effects of Cell‐Scale Microwells on Epithelial Cell Phenotype

Advanced Functional Materials, EarlyView.
In small polycaprolactone microwells, A549 epithelial cells span well edges, in contrast to cells growing on flat substrates. Focal adhesion sites (yellow) concentrate at topographic boundaries, while cytoskeletal tension (magenta stress fibers) is transmitted to the nucleus (blue), reducing nuclear sphericity.
Ruiwen He, Wang Sik Lee, Phattadon Yajan, Aaron Lee, Mauro Sousa de Almeida, Sandeep Keshavan, Jozef Adamcik, Céline Loussert‐Fonta, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Alke Petri‐Fink   +10 more
wiley   +1 more source

Text, data and link-mining in digital libraries: looking for the heritage gold

, 2017
Emmanuelle Bermès
openalex   +1 more source

Nanothermometry in Living Cells: Physical Limits, Conceptual and Material Challenges

Advanced Functional Materials, EarlyView.
Heat and temperature are fundamental to life. When nanothermometers began probing regions as small as a living cell, they triggered controversial claims of large intracellular temperature gradients. We review physical constraints energy‐conservation, entropy production, thermodynamic fluctuations, and molecular dynamics.
Taras Plakhotnik
wiley   +1 more source