Results 41 to 50 of about 458,372 (255)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Machine Learning Offers Opportunities to Advance Library Services

Evidence Based Library and Information Practice
A Review of: Wang, Y. (2022). Using machine learning and natural language processing to analyze library chat reference transcripts. Information Technology and Libraries, 41(3). https://doi.org/10.6017/ital.v41i3.14967 Objective – The study sought to
Samantha Kaplan
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Refining Wikidata’s Bibliographic Domain to Increase Reuse in GLAMs

Journal of Open Humanities Data
The Wikidata ontology consists of classes, properties, and subproperties which provide structure to an open and flexible graph-based semantic network. It includes nearly every class in Wikidata, resulting in a large, dynamic ontology.
Kalliopi Mathios, Ege Atacan Doğan, Jeremy Nelson   +2 more
doaj   +1 more source

Simulation-based Verification of System-on-Chip Bus Controllers

Труды Института системного программирования РАН, 2018
The paper presents an approach to verification of commutation components of Systems-on-Chip. The core idea is to verify bus controllers and supporting interface parts connected to a reference model at unit-level.
M. M. Chupilko, E. A. Drozdova
doaj   +1 more source

Design and Implementation of a Library and Information Science Open Access Journal Union Catalogue System [PDF]

Jiàoyù zīliào yǔ túshūguǎn xué, 2017
Open access is a mode of academic communication that has been on the rise in recent years, but open access academic resources are widely dispersed across the internet, making it occasionally inconvenient in terms of its use.
Sinn-Cheng Lin, Ting-Yu Chou
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A Visualization Verification Method for Startup Risk of Substation Equipment Based on Multidimensional Graph Models

Engineering Reports
This article presents a visualization verification method for substation equipment startup risk based on a multidimensional graph model, aiming to enhance the safety and reliability of the equipment startup process.
Lifan Mao, Huang Chen, Yongqi He, Chuanpu Zhu, Chao Chen   +4 more
doaj   +1 more source