Results 241 to 250 of about 1,117,317 (308)

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Enhancing accessibility and equity in utilization of virtual care: Virtual Care @ Your Library pilot project. [PDF]

BMC Health Serv Res
Murphy GT, Sampalli T, Anderson K, Stackhouse E, Pauls M, Ferris M, King C, Koto P, Devereaux E, Abbood H, MacInnis M, Guk J.   +11 more
europepmc   +1 more source

A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model

Advanced Science, EarlyView.
We analyzed long‐read genomic sequencing data obtained from 40 inbred mouse strains to produce a large database of structural variants. This dataset captures the major types of structural variants, which includes deletions, insertions, duplications, and inversions.
Wenlong Ren, Zhuoqing Fang, Egor Dolzhenko, Christopher T. Saunders, Zhuanfen Cheng, Victoria Popic, Gary Peltz   +6 more
wiley   +1 more source

A reference genome assembly for the pink volcano barnacle, Tetraclita rubescens, Nilsson-Cantell, 1931. [PDF]

J Hered
Carlson BJ, DeBiasse MB, Pedraza-Marrón CDR, Escalona M, Chumchim N, Marimuthu MPA, Miller C, Nguyen O, Seligmann WE, Dawson MN.   +9 more
europepmc   +1 more source

Reference Service in the Junior College Library

North Carolina Libraries, 1959
openaire   +1 more source

How AI Shapes the Future Landscape of Sustainable Building Design With Climate Change Challenges?

Advanced Science, EarlyView.
This review examines how artificial intelligence reshapes sustainable building design faced with climate change challenges. The authors synthesize existing studies to demonstrate AI's transformative potential across design lifecycle phases from climate‐aware form generation to performance optimization.
Pengyuan Shen, Xiaoni Gao, Shuai Lu, Yi Zhang, Xing Zheng, Matthaios Santamouris   +5 more
wiley   +1 more source

Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions. [PDF]

Nat Methods
Kotliar D, Curtis M, Agnew R, Weinand K, Nathan A, Baglaenko Y, Slowikowski K, Zhao Y, Sabeti PC, Rao DA, Raychaudhuri S.   +10 more
europepmc   +1 more source

Synergies in Agricultural Biodiversity Conservation: Decomposing the Interaction Between Nature Parks and Agri‐Environment Schemes

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Understanding how policy instruments with overlapping goals interact is crucial for leveraging their synergies. This study explores the mechanisms for regional nature parks (a form of protected areas that impose no restrictions on agriculture) to enhance the adoption of biodiversity‐conserving agri‐environment schemes (AES) in Switzerland ...
Yanbing Wang, Christian Ritzel, Antonia Kaiser, Gabriele Mack   +3 more
wiley   +1 more source

Diagnostic Accuracy of the National Library of Medicine (NLM) Screener Application in Screening for Malaria Parasites Among Blood Donors at the Korle-Bu Blood Bank, Ghana: A Cross-Sectional Study. [PDF]

J Trop Med
Appiah SB, Osei S, Brown NK, Amoah LE, Owusu EDA.   +4 more
europepmc   +1 more source