Results 171 to 180 of about 215,799 (266)

The Interplay Between Molybdopterin Synthase and Metal Metabolism Contributes to Pathogenicity in Acinetobacter baumannii

Advanced Science, EarlyView.
Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao, Wenbo He, Zhenlin Ouyang, Ruochen Wang, Jiaxin Zhang, Xin Liu, Yiting Jing, Qinyue Yu, Xiaoyu He, Qian Qin, Litao Guo, Peter M. Hwang, Fang Zheng, Yurong Wen   +13 more
wiley   +1 more source

Perceptions of digital medical information services applying new technologies. [PDF]

J Med Libr Assoc
Lee GE, Seo J, Choi YJ, Lee JY.
europepmc   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Voters reveal public library value: Evidence from US referendums. [PDF]

PLoS One
Gustina M, Berrens RP.
europepmc   +1 more source

A Damage‐Gated Small‐Molecule Chimera Selectively Enhances Mitophagy by Coupling Dysfunctional Mitochondria to Autophagy

Advanced Science, EarlyView.
MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov, Ekaterina А. Guseva, Alexander Yu. Rudenko, Konstantin G. Lyamzaev, Sofya Y. Sokolskaya, Julia A. Golubeva, Maria V. Belopolskaya, Nadezda V. Andrianova, Olga V. Fadeeva, Elena О. Morgun, Elena A. Tukhovskaya, Marina S. Kazakova, Vladimir M. Pavlov, Daria K. Yagoda, Elena I. Marusich, Rose‐Lys Zaranaina, Valeriya B. Vays, Irina M. Vangeli, Egor Y. Plotnikov, Maxim L. Lovat, Lora E. Bakeeva, Arkady N. Murashev, Vladimir I. Polshakov, Olga A. Dontsova, Peter V. Sergiev   +24 more
wiley   +1 more source

TIPIN Couples Epigenetic Rewiring to EGFR Stabilization and Lenvatinib Resistance in Liver Cancer

Advanced Science, EarlyView.
DNA hypomethylation elevates TIPIN expression in liver cancer. TIPIN competes with E3 ligase c‐Cbl for the EGFR intracellular domain, inhibiting EGFR ubiquitination and lysosomal degradation to sustain oncogenic EGFR‐ ERK signaling. High TIPIN confers lenvatinib resistance, while TIPIN depletion restores drug sensitivity in liver cancer. ABSTRACT Aims:
Xing Jia, Shiyu Zhang, Yangbo Tang, Shinuo Chen, Xingxin Zhu, Junran Chen, Suchen Bian, Lei Zheng, Chi Zhang, Haojing Ma, Wengfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Qinglin Li, Penghong Song   +15 more
wiley   +1 more source

Standards for vision science librarians: 2026 review and revisions. [PDF]

J Med Libr Assoc
Edmonds H, Alcorn KS, Allen C, Barreras R, Rios D, Holland L, Kumaragurupari T.   +6 more
europepmc   +1 more source

Bacillus Licheniformis‐Induced Cognitive Decline in Mice Linking Gut Microbiota Dysbiosis, Metabolic Perturbations, and Hippocampal Neuroinflammation

Advanced Science, EarlyView.
Chronic oral administration of specific probiotic strains triggers gut microbiota dysbiosis and systemic metabolic perturbations in mice. Multi‐omics profiling reveals subsequent hippocampal glial remodeling and neuroinflammation, which are linked to cognitive impairment.
Yibin Lin, Afeng Wang, Hongchang Zhou, Yuliang Sun, Yingying Guo, Keyu Chen, Junhong Sun, Tinliang Lin, Zhaochen Huang, Xinhua Qiang, Jie He, Jianlin Lou, Yunliang Yao, Shengwen Shao, Yongliang Pan, Xiang Wang   +15 more
wiley   +1 more source

When patrons "click" with the library's literature searches: using data from a novel link generation process to assess patron engagement with literature search results. [PDF]

J Can Health Libr Assoc
Ostapyk T, Askin N, Epp C, Tichon JG.
europepmc   +1 more source

A Transcriptionally Distinct Intermediate Activation State Precedes Langerhans Cell Migration From the Epidermis

Advanced Science, EarlyView.
A transcriptionally distinct intermediate Langerhans cell state is identified between steady and migratory populations during skin injury. Integrated single‐cell transcriptomics, flow cytometry, and intravital imaging reveal state‐specific markers and implicate complement signaling, particularly C3, in regulating Langerhans cell accumulation near ...
Artem Kiselev, Axel D. Schmitter‐Sánchez, Sudhanshu Mishra, Hyeri Kim, Sharod Williams, Sangbum Park   +5 more
wiley   +1 more source