Results 181 to 190 of about 6,725,926 (309)
A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness
Advanced Science, EarlyView.Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger +17 more
wiley +1 more source
Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders
Advanced Science, EarlyView.This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin +8 more
wiley +1 more source
The Review of IFLA Guidelines for Library Services for People with Dementia
, 2012 Ljiljana Sabljak
openalex +1 more source
Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression
Advanced Science, EarlyView.Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li +4 more
wiley +1 more source
Advanced Science, EarlyView.Cysteine‐tagged silk‐elastin‐like proteins, a family of tri‐block chimeric proteins that consist of a photothermal agent binding motif, silk motif, and elastin motif is developed to form a responsive in situ hydrogel for late‐stage and metastatic triple‐negative breast cancer.
Xinchen Shen +11 more
wiley +1 more source
Advanced Science, EarlyView.Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei +8 more
wiley +1 more source
University Library Intellectual Property Information Service Exploration and Practice — Taking Huazhong University of Science and Technology as an Example [PDF]
, 2019 Lingling Peng, Chi Zhang
openalex +1 more source
Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids
Advanced Science, EarlyView.To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun +9 more
wiley +1 more source