Results 41 to 50 of about 7,064,102 (309)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Library Publishing Services:

Something's Gotta Give, 2012
In 2007, 65% of ARL members were reported to be either offering or developing publishing services (Hahn, 2008). A new survey, conducted by Purdue University, Georgia Tech, and University of Utah Libraries as part of an IMLS-funded research project, suggests that almost 80% of ARL members are now offering publishing services and that this is also an ...
Watkinson, Charles, Murray-Rust, Catherine, Nesdill, Daureen, Mower, Allyson   +3 more
openaire   +4 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

PUG-View: programmatic access to chemical annotations integrated in PubChem

Journal of Cheminformatics, 2019
PubChem is a chemical data repository that provides comprehensive information on various chemical entities. It contains a wealth of chemical information from hundreds of data sources.
Sunghwan Kim, Paul A. Thiessen, Tiejun Cheng, Jian Zhang, Asta Gindulyte, Evan E. Bolton   +5 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Competències professionals per als bibliotecaris dels serveis de referència i atenció a l'usuari

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2003
Directriu elaborada la RUSA Task Force on Professional Competencies per proveïr a bibliotecaris, biblioteques i centres d’informació d’una pauta modèlica sobre les competències essencials per reeixir en els serveis de referència i atenció a l’usuari.
American Library Association. Reference and User Services Association
doaj  

Management of Open Education Resources in Academic Libraries of Nigerian Public Universities

Open Information Science
With the growth of open educational resources (OERs), academic libraries have an opportunity to play a vital role in facilitating access, use, and development of OERs.
Salau Sadiat Adetoro, Adamu Abu Ahmed, Salami Rita Otibhor   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Directrius per a la preparació d'una bibliografia

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2002
Traducció al català de les Guidelines for the preparation of a bibliography de la RUSA’s Standards and Guidelines Committee. Aquestes directrius reflecteixen els desenvolupaments tecnològics des de l’àmplia difusió de les bibliografies a internet i fan ...
American Library Association. Reference and User Services Association
doaj  

Academic health sciences libraries and affiliated hospitals: a conversation about licensing electronic resources

Journal of the Medical Library Association, 2020
Objective: Libraries in academic health centers may license electronic resources for their affiliated hospitals, as well as for their academic institutions.
Amy E. Allison, Bonita Bryan, Sandra G. Franklin, Leslie C. Schick   +3 more
doaj   +1 more source