Results 31 to 40 of about 1,205,678 (309)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Google Me This: What Can Project Management Be for Libraries in the Age of Google et al.? [PDF]

Revista Română de Biblioteconomie și Știința Informării, 2017
Given the challenges the libraries are facing in pursuit of adapting to the changes of the new century’s information and communication revolution, using project management as proficiency instrument for taming these challenges can be beneficial for ...
Elena Cătălina Rojișteanu
doaj   +1 more source

Creating and customizing digital library collections with the Greenstone Librarian Interface [PDF]

, 2004
The Greenstone digital library software is a comprehensive system for building and distributing digital library collections. It provides a new way of organizing information and publishing it on the Internet.
Witten, Ian H.
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Challenges for Libraries in Difficult Economic Times: Evidence from the UK

Liber Quarterly: The Journal of European Research Libraries, 2010
The last decade has been a period of unprecedented change for university libraries. The rapid growth in numbers of students and staff across the university sector has been accompanied by the move to a substantially digital environment with some ...
Michael Jubb
doaj   +1 more source

BibToGo – Der Digitale Bibliotheksausweis des Goethe-Instituts

Bibliothek, 2022
Warum eigentlich nicht auch die Bibliotheksmitgliedschaft digitalisieren? Der digitale Bibliotheksausweis des Goethe-Instituts macht Plastikkarten überflüssig und bündelt gleichzeitig das digitale Gesamtangebot der Bibliotheken in einer einzigen ...
Sandfuchs Nico
doaj   +1 more source

Data-Driven Decisions for Library Liaisons: Exploring Strategies for Effectively Managing Diminishing Monograph Collections [PDF]

, 2012
Many academic libraries have liaison programs as a means of building relevant and useful library collections and to promote library resources to campus users. Librarians have long served as liaisons without the benefit of much data to guide decisions. In
Jensen, Karen
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The University Library - an Intercultural and Multicultural Space

Revista Română de Biblioteconomie și Știința Informării, 2018
The 21st-century university library is a space hosting a multicultural education process, whether by design, with a clear strategy, or in an unstructured, yet natural manner. For that reason, my aim is to identify aspects of multiculturalism in the Eugen
Manuela Zănescu
doaj   +1 more source