Results 41 to 50 of about 1,205,678 (309)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

A Few Words About Akribie

open access: yesInformation for Social Change, 1996
Akribie (which in German means the quality of exactness or accuracy), the Working Group of Critical Librarians, has been meeting since 1988. We work in libraries in West Germany, in all areas of specialisation.
Maria Kuhn-Ludewig
doaj   +1 more source

Users' Perceptions of Library Service Quality: A LibQUAL+ Qualitative Study [PDF]

open access: yes, 2001
published or submitted for ...
Cook, Colleen, Heath, Fred M.
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Use of EZProxy to access international journals among students of Library and Information Science, University of Indonesia

open access: yesRecord and Library Journal, 2016
Student’s magister is one of user library university of Indonesia those who need information regarding duty as carried out college.  With different backgrounds students as, made they need facilities sources of information easy and efficient.
Rusdiyah Ciptaning Dwi Kusuma
doaj   +1 more source

Law Libraries and Their Users [PDF]

open access: yes, 2018
Preprint of revised and updated chapter by Jules Winterton, Director, Institute of Advanced Legal Studies.\ud \ud Thoroughly updated to reflect changes in law libraries and their users – including new information technologies such as social networking and communication.
openaire   +1 more source

Computer-based library or computer-based learning? [PDF]

open access: yes, 2010
Traditionally, libraries have played the role of repository of published information resources and, more recently, gateway to online subscription databases. The library online catalog and digital library interface serve an intermediary function to help
Khoo, S.G. Christopher
core  

Identifying customer expectations is key to evidence based service delivery [PDF]

open access: yes, 2010
As librarians and information professionals we share a common rationale: to deliver enhanced services for our customers. The importance of this is self-evident - if we don’t have customers we don't have a job. We therefore put our services at peril if we
Booth, A, McKnight, S
core   +2 more sources

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