Results 91 to 100 of about 24,208,438 (307)

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

open access: yesAdvanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao   +20 more
wiley   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

open access: yesAdvanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu   +14 more
wiley   +1 more source

The Usability Evaluation Study of University Library Websites

open access: yes, 2010
[[abstract]]Library websites are the platforms that libraries extend their services to. In addition to concerning the contents of library websites, their easy understand- ing and flexible usage are the most important issues that are liable to disregard ...
Shieh, Jiann-Cherng;Liu, Chih-Feng   +1 more
core  

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

open access: yesAdvanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu   +12 more
wiley   +1 more source

Fiction mediation on library websites

open access: yes, 2010
Mediation of fiction has always been one of the main tasks of the public library. The focus on information technology is often seen as a threat and competitor to this task.
Berling, Charlotte
core   +2 more sources

Social Proof: A Tool for Determining Authority

open access: yesIn the Library with the Lead Pipe, 2009
In the Library with the Lead Pipe is pleased to welcome another guest author, Steve McCann! Steve is a Digital Projects Librarian specializing in information architecture, usability studies, and data analysis.
Steve McCann
doaj  

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

open access: yesAdvanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng   +13 more
wiley   +1 more source

Conceptualising quality early childhood education: Learning from young children in Brazil and South Africa through creative and play‐based methods

open access: yesBritish Educational Research Journal, EarlyView., 2023
Abstract Early childhood has increasingly been acknowledged as a vital time for all children. Inclusive and quality education is part of the United Nations Sustainable Development Goals, with the further specification that all children have access to quality pre‐primary education.
Laura H. V. Wright   +8 more
wiley   +1 more source

Usability evaluation of an academic library website

open access: yesPakistan Journal of Information Management & Libraries, 2012
The focus of the study was the usability evaluation of the Punjab University Library (PUL) website. The main objectives of the study were to ascertain the feelings of website users along with the efficiency of the system with reference to its goals and ...
Memoona Iqbal, Nosheen Fatima Warraich
doaj  

Darien Volunteer Library Card

open access: yes, 1978
Darien Volunteer Library ...
Indian Prairie Public Library
core  

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