CDT1, a licensing factor that limits rereplication. [PDF]
Mol Cell, 2023 Cells must avoid licensing of neosynthesized DNA to prevent rereplication. In this issue of Molecular Cell, Ratnayeke et al. (2022)1 reveal how the licensing factor CDT1, prior to its degradation, inhibits DNA elongation by suppressing CMG helicase progression at replication forks.
Rona G, Pagano M.
europepmc +5 more sources
DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6 [PDF]
Nature Communications, 2017 Centrosome duplication is synchronized with cell cycle events but how this is regulated at a molecular level is unclear. Here, the authors show that the DNA replication licensing factor Cdc6 restrains centrosome duplication via binding and inhibiting Sas-
Xiaowei Xu +9 more
doaj +4 more sources
CDC6, a key replication licensing factor, is overexpressed and confers poor prognosis in diffuse large B-cell lymphoma [PDF]
BMC Cancer, 2023 Background Cell division cycle 6 (CDC6) is a key licensing factor in the assembly of pre-replicative complexes at origins of replication. The role of CDC6 in the pathogenesis of in diffuse larger B-cell lymphoma (DLBCL) remains unknown.
Mingfang Shen +7 more
doaj +4 more sources
Endogenous royalty factor in a licensing contract [PDF]
Yugoslav Journal of Operations Research, 2016 The owner of a well known fashion brand grants a manufacturer the rights to produce and sell a second-line brand against a percentage of the sales called royalty.
Buratto Alessandra +2 more
doaj +2 more sources
Licensing factors lose their credentials [PDF]
Journal of Cell Biology, 2012 ![Figure][1] As anaphase progresses (left to right), more and more Mcm3 protein (glowing dots) attaches to the DNA. Sonneville et al. reveal how C. elegans embryos control replication licensing factors to promote efficient DNA duplication while preventing the genome from being copied ...
Leslie Mitch
openalex +3 more sources
Robust Replication Control Is Generated by Temporal Gaps between Licensing and Firing Phases and Depends on Degradation of Firing Factor Sld2 [PDF]
Cell Reports, 2016 Temporal separation of DNA replication initiation into licensing and firing phases ensures the precise duplication of the genome during each cell cycle.
Karl-Uwe Reusswig +3 more
doaj +2 more sources
Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions [PDF]
Nature CommunicationsDNA replication is tightly regulated to occur once per cell cycle, with the MCM2-7 helicase loaded onto replication origins only during G1-phase. In higher eukaryotes, geminin negatively regulates this process during S-, G2- and M-phases by binding the ...
Joshua Tomkins +13 more
doaj +2 more sources
Perceived organizational status and bootleg innovation: the role of moral licensing in breaking rules [PDF]
BMC PsychologyBackground Bootleg innovation differs from traditional innovation in that it involves actions that either contravene established organizational rules and procedures or are conducted autonomously and covertly by individuals, with the aim of benefiting the
Du-Juan Huang +3 more
doaj +2 more sources
International Journal of Technology, 2019 This study aims to identify the success factors involved in improving the building permit, or Izin Mendirikan Bangunan (IMB), licensing service in Denpasar City, Bali Province. These permits play an important role in providing legal ...
Nyoman Budiartha Raka Mandi +2 more
doaj +2 more sources
Simvastatin suppresses the DNA replication licensing factor MCM7 and inhibits the growth of tamoxifen-resistant breast cancer cells. [PDF]
Sci Rep, 2017 Liang Z +14 more
europepmc +3 more sources