DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6 [PDF]
Nature Communications, 2017 Centrosome duplication is synchronized with cell cycle events but how this is regulated at a molecular level is unclear. Here, the authors show that the DNA replication licensing factor Cdc6 restrains centrosome duplication via binding and inhibiting Sas-
Xiaowei Xu +9 more
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Robust Replication Control Is Generated by Temporal Gaps between Licensing and Firing Phases and Depends on Degradation of Firing Factor Sld2 [PDF]
Cell Reports, 2016 Temporal separation of DNA replication initiation into licensing and firing phases ensures the precise duplication of the genome during each cell cycle.
Karl-Uwe Reusswig +3 more
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CDC6, a key replication licensing factor, is overexpressed and confers poor prognosis in diffuse large B-cell lymphoma [PDF]
BMC Cancer, 2023 Background Cell division cycle 6 (CDC6) is a key licensing factor in the assembly of pre-replicative complexes at origins of replication. The role of CDC6 in the pathogenesis of in diffuse larger B-cell lymphoma (DLBCL) remains unknown.
Mingfang Shen +7 more
doaj +4 more sources
Simvastatin suppresses the DNA replication licensing factor MCM7 and inhibits the growth of tamoxifen-resistant breast cancer cells. [PDF]
Sci Rep, 2017 Acquired tamoxifen resistance (TamR) remains a major challenge in breast cancer endocrine therapy. The mechanism of acquiring tamoxifen resistance remains elusive, and no effective drugs are available.
Liang Z +14 more
europepmc +4 more sources
Simvastatin and Atorvastatin inhibit DNA replication licensing factor MCM7 and effectively suppress RB-deficient tumors growth. [PDF]
Cell Death Dis, 2017 Loss or dysfunction of tumor suppressor retinoblastoma (RB) is a common feature in various tumors, and contributes to cancer cell stemness and drug resistance to cancer therapy.
Li J +15 more
europepmc +4 more sources
The role of cytokine licensing in shaping the therapeutic potential of wharton’s jelly MSCs: metabolic shift towards immunomodulation at the expense of differentiation [PDF]
Stem Cell Research & TherapyBackground Cytokine licensing with pro-inflammatory molecules, such as tumour necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ), has emerged as a promising strategy to enhance the therapeutic potential of multipotent mesenchymal stromal cells ...
Olena Rogulska +12 more
doaj +2 more sources
International Journal of Technology, 2019 This study aims to identify the success factors involved in improving the building permit, or Izin Mendirikan Bangunan (IMB), licensing service in Denpasar City, Bali Province. These permits play an important role in providing legal ...
Nyoman Budiartha Raka Mandi +2 more
doaj +2 more sources
Frontiers in Pharmacology, 2021 Geminin, an inhibitor of the DNA replication licensing factor, chromatin licensing and DNA replication factor (Cdt) 1, is essential for the maintenance of genomic integrity. As a multifunctional protein, geminin is also involved in tumor progression, but
Haile Zhao +5 more
doaj +1 more source
Endogenous royalty factor in a licensing contract [PDF]
Yugoslav Journal of Operations Research, 2016 The owner of a well known fashion brand grants a manufacturer the rights to produce and sell a second-line brand against a percentage of the sales called royalty.
Buratto Alessandra +2 more
doaj +1 more source
Licensing and certification of transport services
Авіаційно-космічна техніка та технологія, 2023 This article is devoted to the analysis of the processes of licensing and certification of transport services in Ukraine. The subject of the study is the process of licensing and certification of transport services, in particular the study of its ...
Inesa Halona +2 more
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