Results 101 to 110 of about 13,046,870 (318)

Proteolysis of DNA Replication Licensing Factor Cdt1 in S-phase Is Performed Independently of Geminin through Its N-terminal Region*

Journal of Biological Chemistry, 2004
Licensing of replication origins is carefully regulated in a cell cycle to maintain genome integrity. Using an in vivo ubiquitination assay and temperature-sensitive cell lines we demonstrate that Cdt1 in mammalian cells is degraded through ubiquitin ...
H. Nishitani, Z. Lygerou, T. Nishimoto
semanticscholar   +1 more source

Detecting Dengue in Flight: Leveraging Machine Learning to Analyze Mosquito Flight Patterns for Infection Detection

Advanced Biology, EarlyView.
Dengue infection alters mosquito flight behavior, enabling detection using machine learning classifiers. This study analyzes 3D flight trajectories and evaluates multiple models, showing that longer sequence lengths improve classification performance.
Nouman Javed, Adam J. López‐Denman, Prasad N. Paradkar, Asim Bhatti   +3 more
wiley   +1 more source

Machine Learning Applied to High Entropy Alloys under Irradiation

Advanced Engineering Materials, EarlyView.
Designing alloys for extreme environments demands fast, trustworthy prediction. This review charts how machine learning—especially machine‐learned interatomic potentials and predictive models based on experiment‐informed datasets—captures the complexity of high‐entropy alloys in extreme environments, predicts phase formation, mechanical properties, and
Amin Esfandiarpour, Sri Tapaswi Nori, Silvia Bonfanti, Mikko Alava, Antoni Wadowski, Wenyi Huo, Łukasz Kurpaska, Michał Pecelerowicz, Jan S. Wróbel   +8 more
wiley   +1 more source

Permissive beliefs in the context of gaming, online shopping and alcohol drinking – Systematic development of a self-report measure

Comprehensive Psychiatry
Background: The activation of permissive beliefs is a cognitive mechanism through which individuals permit themselves to engage in pleasurable, yet potentially unregulated activities.
Annika Brandtner, Silke M. Müller, Sofie Behrens, Andreas Oelker, Matthias Brand   +4 more
doaj   +1 more source

CDT1, a licensing factor that limits rereplication. [PDF]

Mol Cell, 2023
Rona G, Pagano M.
europepmc   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

The association of USMLE Step 1 and Step 2 CK scores with residency match specialty and location

Medical Education Online, 2017
Background: For future physicians, residency programs offer necessary extended training in specific medical specialties. Medical schools benefit from an understanding of factors that lead their students to match into certain residency specialties.
Jacqueline L. Gauer, J. Brooks Jackson
doaj   +1 more source

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

eLife, 2017
Proteolytic cleavage and release from the cell surface of membrane-tethered ligands is an important mechanism of regulating intercellular signalling. TACE is a major shedding protease, responsible for the liberation of the inflammatory cytokine TNFα and ...
Adam Graham Grieve, Hongmei Xu, Ulrike Künzel, Paul Bambrough, Boris Sieber, Matthew Freeman   +5 more
doaj   +1 more source

Cost Escalation in Nuclear Power [PDF]

, 1978
This report is concerned with the escalation of capital costs of nuclear central station power plants between the early 1960s and the present. The report presents an historical overview of the development of the nuclear power industry and cost escalation
Montgomery, W. David, Quirk, James P.
core  

The SCFSkp2 Ubiquitin Ligase Complex Interacts with the Human Replication Licensing Factor Cdt1 and Regulates Cdt1 Degradation*

Journal of Biological Chemistry, 2003
DNA replication initiation is tightly controlled so that each origin only fires once per cell cycle. Cell cycle-dependent Cdt1 degradation plays an essential role in DNA replication control, as overexpression of Cdt1 leads to re-replication.
Xianghong Li, Qi-Peng Zhao, Rong Liao, Peiqing Sun, Xiaohua Wu   +4 more
semanticscholar   +1 more source