The Licensing Factor Cdt1 Links Cell Cycle Progression to the DNA Damage Response [PDF]
Anticancer Research, 2020 The maintenance of genome integrity is essential for cellular survival and propagation. It relies upon the accurate and timely replication of the genetic material, as well as the rapid sensing and repairing of damage to DNA.
Αλεξάνδρα Κανέλλου +4 more
openalex +2 more sources
The DNA Replication Licensing Factor Miniature Chromosome Maintenance 7 Is Essential for RNA Splicing of Epidermal Growth Factor Receptor, c-Met, and Platelet-derived Growth Factor Receptor [PDF]
Journal of Biological Chemistry, 2014 Background: Miniature chromosome maintenance 7 (MCM7) is a pivotal DNA replication licensing factor. Results: MCM7 interacts with splicing factor 3B, subunit 3 (SF3B3).
Zhanghui Chen +4 more
openalex +2 more sources
Stress-Stimulated Mitogen-Activated Protein Kinases Control the Stability and Activity of the Cdt1 DNA Replication Licensing Factor [PDF]
Molecular and Cellular Biology, 2011 Srikripa Chandrasekaran +3 more
openalex +2 more sources
DNA Replication Licensing Factor MCM3 [PDF]
Definitions, 2020 National Cancer Institute
openalex +2 more sources
Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis. [PDF]
Cell Cycle, 2015 To maintain genome stability, the thousands of replication origins of mammalian genomes must only initiate replication once per cell cycle. This is achieved by a strict temporal separation of ongoing replication in S phase, and the formation of pre ...
Kalfalah FM +6 more
europepmc +2 more sources
SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P. [PDF]
Mol Cell BiolSREBP transcription factors are central regulators of lipid metabolism. Their proteolytic activation requires ER to the Golgi translocation and subsequent cleavage by site-1-protease (S1P).
Hendrix S +10 more
europepmc +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2006 Ivan V. Litvinov +6 more
openalex +2 more sources
Coordinated Activation of the Origin Licensing Factor CDC6 and CDK2 in Resting Human Fibroblasts Expressing SV40 Small T Antigen and Cyclin E [PDF]
Journal of Biological Chemistry, 2009 We have previously shown that SV40 small t antigen (st) cooperates with deregulated cyclin E to activate CDK2 and bypass quiescence in normal human fibroblasts (NHF).
Elena Sotillo +5 more
openalex +2 more sources
Frontiers in Pharmacology, 2022 DNA replication initiation requires the loading of MCM2-7 complexes at the origins of replication during G1. Replication licensing renders chromatin competent for DNA replication and its tight regulation is essential to prevent aberrant DNA replication ...
Nikolaos Karantzelis +10 more
doaj +1 more source