Results 41 to 50 of about 13,046,870 (318)

Patents and Competition in the Automobile Industry [PDF]

, 1948
Methane (CH4) fluxes from world rivers are still poorly constrained, with measurements restricted mainly to temperate climates. Additional river flux measurements, including spatio-temporal studies, are important to refine extrapolations.
Welsh, C. A.
core   +4 more sources

THE EFFICACY OF MOTORCYCLE TRAINING TO REDUCE SELF-REPORTED NEGATIVE BEHAVIOUR AND ATTITUDE (CASE STUDY IN UK AND INDONESIA)

Journal of the Civil Engineering Forum, 2014
Motorcyclists are vulnerable road users because of their particular combination of physical vulnerability. Motorcyclists’ training and licensing system have already implemented in so many countries in the world particularly developed countries.
Winna Justiana Sirait, Sigit Priyanto, Samantha Jamson   +2 more
doaj   +1 more source

The Caenorhabditis elegans Replication Licensing Factor CDT-1 Is Targeted for Degradation by the CUL-4/DDB-1 Complex

Molecular and Cellular Biology, 2006
Young‐Jo Kim, Edward T. Kipreos
openalex   +2 more sources

HBx Protein of Hepatitis B Virus Promotes Reinitiation of DNA Replication by Regulating Expression and Intracellular Stability of Replication Licensing Factor CDC6*

Journal of Biological Chemistry, 2012
Background: CDC6 is a replication licensing factor, which is tightly regulated to prevent reinitiation of replication. Results: Hepatitis B virus HBx protein up-regulates CDC6 both transcriptionally as well as post-transcriptionally and promotes its ...
V. Pandey, Vijay Kumar
semanticscholar   +1 more source

Bayesian inference and non-linear extensions of the CIRCE method for quantifying the uncertainty of closure relationships integrated into thermal-hydraulic system codes

, 2020
Uncertainty Quantification of closure relationships integrated into thermal-hydraulic system codes is a critical prerequisite in applying the Best-Estimate Plus Uncertainty (BEPU) methodology for nuclear safety and licensing processes.The purpose of the ...
Damblin, Guillaume, Gaillard, Pierre
core   +2 more sources

Forecasting Technology Trends through the Gap Between Science and Technology: The Case of Software as an E-Commerce Service

Foresight and STI Governance, 2021
Identifying technology trends can be a key success factor for companies to be competitive and take advantage of technological trends before they occur. The companies always work to plan for future products and services. For that, it is important to turn
Tugrul Daim, Esraa Bukhari, Dana Bakry, James VanHuis, Haydar Yalcin, Xiaoli Wang   +5 more
doaj   +1 more source

Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage

Journal of Cell Science, 2011
For genomic integrity to be maintained, the cell cycle and DNA damage responses must be linked. Cdt1, a G1-specific cell-cycle factor, is targeted for proteolysis by the Cul4-Ddb1Cdt2 ubiquitin ligase following DNA damage.
Vassilis Roukos, A. Kinkhabwala, J. Colombelli, P. Kotsantis, S. Taraviras, H. Nishitani, E. Stelzer, P. Bastiaens, Z. Lygerou   +8 more
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source