Results 51 to 60 of about 318,687 (321)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Pengaruh Kepemimpinan Transformasional Terhadap Kinerja Pegawai Pada BPMPT Provinsi Jawa Barat
Jurnal Kepariwisataan, 2018 The main problem in this research is the performance of employees of Investment Board and Integrated Licensing (BPMPT) West Java Province felt very less. The problem is caused by the absence of optimal transformational leadership.
Indra Saftara
doaj +1 more source
Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]
, 2012 Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core
Patenting and licensing of university research: promoting innovation or undermining academic values? [PDF]
, 2011 Since the 1980s in the US and the 1990s in Europe, patenting and licensing activities by universities have massively increased. This is strongly encouraged by governments throughout the Western world.
A Geuna +40 more
core +2 more sources
Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage [PDF]
Journal of Cell Science, 2011 For genomic integrity to be maintained, the cell cycle and DNA damage responses must be linked. Cdt1, a G1-specific cell-cycle factor, is targeted for proteolysis by the Cul4-Ddb1Cdt2 ubiquitin ligase following DNA damage. Using a laser nanosurgery microscope to generate spatially restricted DNA damage within the living cell nucleus, we show that Cdt1 ...
Roukos, V. +8 more
openaire +3 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Foresight and STI Governance, 2021 Identifying technology trends can be a key success factor for companies to be competitive and take advantage of technological trends before they occur. The companies always work to plan for future products and services. For that, it is important to turn
Tugrul Daim +5 more
doaj +1 more source
Analisis Kinerja Organisasi Badan Pelayanan Perijinan Terpadu Kota Semarang (Studi Kasus pada Bidang Perijinan Kesejahteraan Rakyat dan Lingkungan) [PDF]
, 2016 The success a government can be seen from quality of public service received by society. The level of public service depend on performance of birocracy as public service administrator.
Gutama, M. A. (Mona) +3 more
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
JPPI (Jurnal Penelitian Pendidikan Indonesia)The provisions of Law No.11 of 2020 concerning Job Creation stipulate the use of the Risk-Based Business Licensing Service System (OSS RBA), which regulates licensing based on the level of business risk.
Fitri Yunianto Hapsari +2 more
doaj +1 more source