Results 51 to 60 of about 13,046,870 (318)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Pengaruh Kepemimpinan Transformasional Terhadap Kinerja Pegawai Pada BPMPT Provinsi Jawa Barat
Jurnal Kepariwisataan, 2018 The main problem in this research is the performance of employees of Investment Board and Integrated Licensing (BPMPT) West Java Province felt very less. The problem is caused by the absence of optimal transformational leadership.
Indra Saftara
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Frontiers in Microbiology, 2018 The human pathogen, Vibrio cholerae, belongs to the 10% of bacteria in which the genome is divided. Each of its two chromosomes, like bacterial chromosomes in general, replicates from a unique origin at fixed times in the cell cycle. Chr1 initiates first,
Peter N. Ciaccia +2 more
doaj +1 more source
Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]
, 2012 Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
JPPI (Jurnal Penelitian Pendidikan Indonesia)The provisions of Law No.11 of 2020 concerning Job Creation stipulate the use of the Risk-Based Business Licensing Service System (OSS RBA), which regulates licensing based on the level of business risk.
Fitri Yunianto Hapsari +2 more
doaj +1 more source
Известия высших учебных заведений: Геология и разведка, 2021 Background. Three prospective sedimentary complexes — Aptian-Upper Cretaceous, Paleogene and Neogene — are predicted in the waters of the Eastern Arctic seas.
E. A. Lavrenova +2 more
doaj +1 more source
Analisis Kinerja Organisasi Badan Pelayanan Perijinan Terpadu Kota Semarang (Studi Kasus pada Bidang Perijinan Kesejahteraan Rakyat dan Lingkungan) [PDF]
, 2016 The success a government can be seen from quality of public service received by society. The level of public service depend on performance of birocracy as public service administrator.
Gutama, M. A. (Mona) +3 more
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