Results 61 to 70 of about 13,046,870 (318)
Acetylation/Deacetylation Modulates the Stability of DNA Replication Licensing Factor Cdt1*
Journal of Biological Chemistry, 2009 Proper expression of the replication licensing factor Cdt1 is primarily regulated post-translationally by ubiquitylation and proteasome degradation. In a screen to identify novel non-histone targets of histone deacetylases (HDACs), we found Cdt1 as a ...
M. Glozak, E. Seto
semanticscholar +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Authenticating and licensing architecture of data rights in data trade
大数据, 2022 Data is a key factor of production in digital economy and establishing a factor market of data is inevitable.The development of data factor market includes efforts in the fields of the authentication of data rights, object of transaction, pricing ...
Qifeng TANG, Zhiqing SHAO, Yazhen YE
doaj
Governing Board Accountability: Competition, Regulation and Accreditation [PDF]
, 2010 This article examines the three primary ways in which the governing boards of American colleges and universities are held to account: (1) competition; (2) regulation, including state nonprofit corporation laws, tax laws, and licensing laws; and (3 ...
Areen, Judith C.
core +1 more source
FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
A pilot survey of student perceptions on the benefit of the OSCE and MCQ modalities
GMS Journal for Medical Education, 2018 Objective: The objective structured clinical examination (OSCE) has become widely accepted as a form of assessment in medical education. At the same time, the more traditional multiple choice question (MCQ) examinations remain a central modality of ...
Müller, Stefan +3 more
doaj +1 more source
The ASK-SEAT: a competency-based assessment scale for students majoring in clinical medicine
BMC Medical Education, 2022 Background To validate a competency-based assessment scale for students majoring in clinical medicine, ASK-SEAT. Students’ competency growth across grade years was also examined for trends and gaps. Methods Questionnaires were distributed online from May
Linxiang Huang +10 more
doaj +1 more source
“I Have a [Fair Use] Dream”: Historic Copyrighted Works and the Recognition of Meaningful Rights for the Public [PDF]
, 2015 Dr. Martin Luther King wrote and delivered his famous “I Have a Dream” speech more than fifty years ago. When he obtained copyright protection on the speech in 1963, Dr.
Langvardt, Arlen W.
core +1 more source
HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1.
Genes & Development, 2008 HBO1 histone acetylase is important for DNA replication licensing. In human cells, HBO1 associates with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is ...
B. Miotto, K. Struhl
semanticscholar +1 more source
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source