Results 71 to 80 of about 2,627 (138)

Elevated IL‐4 and IL‐13 Expression in Hailey‐Hailey Disease: Evidence for Th2‐Mediated Pathogenesis and Targeted Treatment

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Hailey‐Hailey disease (HHD) is a rare autosomal dominant blistering disorder caused by mutations in the ATP2C1 gene, which impair keratinocyte adhesion through disrupted calcium signaling. While traditionally considered a structural defect, recent studies suggest that Th2‐mediated inflammation may exacerbate disease pathology ...
Simonetta I. Gaumond, Victoria Soto, Beatriz Abdo Abujamra, Franco Rongioletti, John A. McGrath, Ivan Jozic, Paolo Romanelli   +6 more
wiley   +1 more source

Lichenoid and Granulomatous Stomatitis: Three Additional Cases and Detailed Immunohistochemical Analysis

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Lichenoid and granulomatous stomatitis (LGS) is a rare condition, with clinicopathological features resembling lichenoid and granulomatous dermatitis. Despite increasing reports, its etiology remains unclear and detailed immunohistochemical (IHC) studies are lacking.
Mariana Paravani Palaçon, Karina Kendelhy Santos, Karina Helen Martins, Cecília Aparecida de Oliveira Campos, Ana Terezinha Marques Mesquita, Evânio Vilela Silva, Thales Peres Candido Moreira, Gabriel Enrique Tantalean Laor, Victor Hugo Toral‐Rizo, Alan Grupioni Lourenço, Heitor Albergoni Silveira, Jorge Esquiche León, Andreia Bufalino   +12 more
wiley   +1 more source

Phenotypes and clinical outcomes in children with moderate‐to‐severe atopic dermatitis across diverse ancestries: a Spanish multicenter observational study and cluster analysis (AD‐SKINS Project)

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Atopic dermatitis (AD) has a highly variable clinical phenotype and ancestry can contribute to this heterogeneity. This study aims to identify clinical phenotypes of AD in children from diverse ancestry groups, evaluate clinical outcomes and response to treatment, and define phenotypic clusters with potential relevance.
Eugeni Prat‐Colilles, Adrià Plana‐Pla, Asunción Vicente, Eulàlia Baselga, Helena Iznardo, Esther Roé, Miquel Casals‐Andreu, Maria Sin‐Soler, Josep A. Pujol‐Montcusí, Maria del Mar Cordellat‐Martínez, Xavier Soria‐Gili, Maria del Mar Tapias‐Terré, Marta Bertolin‐Colilla, Nidia Planella‐Fontanillas, Laura Marques‐Martín, Mónica Munera‐Campos, Maria Fabregat‐Pratdepadua, Carolina S. Prat‐Torres, Marta Ivars, Luisa F. Montenegro‐Morillo, Isabel Bielsa‐Marsol, Jose‐Manuel Carrascosa‐Carrillo   +21 more
wiley   +1 more source

Multiclass convolutional neural network vs. 96 dermatologists in skin lesion diagnosis, an international study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Artificial intelligence was shown to improve diagnostic accuracy for skin cancer detection. While most clinically approved models provide binary “benign/malignant” classifications, multiclass predictions may offer greater clinical utility.
Katharina Susanne Kommoss, Julia Katharina Winkler, Anastasia Sophie Vollmer, Christine Mueller‐Christmann, Ferdinand Toberer, Wilhelm Stolz, Teresa Kraenke, Rainer Hofmann‐Wellenhof, Andreas Blum, Alexander Enk, Albert Rosenberger, Holger Andreas Haenssle   +11 more
wiley   +1 more source

Cold plasma treatment for oral lichen planus: a retrospective case collection and proposal of a new clinical score

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Oral lichen planus (OLP) is a chronic autoimmune mucosal disease with malignant potential and limited treatment options. This study evaluated the long‐term efficacy and safety of cold atmospheric plasma (CAP) therapy in therapy‐refractory OLP and introduced the novel Lichen Planus Severity Score (LPSS).
Christian Seebauer, Hans‐Robert Metelmann, Mohamed Falougy, Wolfram Kaduk, Lasse Kremer, Georg Daeschlein   +5 more
wiley   +1 more source

Expression of cdk4 and p16 in Oral Lichen Planus

eJournal of Oral Maxillofacial Research, 2015
Objectives: The purpose of this study was to evaluate the expression of cdk4 and p16, the proteins implicated in hyperproliferation and arrest in oral lichen planus and to compare their expression in erosive and non-erosive oral lichen planus and with ...
Sinny Goel, Nita Khurana, Akanksha Marvah, Sunita Gupta   +3 more
doaj   +1 more source

AI‐Assisted Fungal Detection in Dermatopathology: A Study on Accuracy, Efficiency, and Usability

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives AI‐based image analysis is increasingly applied in pathology. Excluding fungal elements in PAS‐stained skin sections is labor‐intensive and well suited for AI assistance. While fungal detection in nails has been studied, skin‐biopsy applications and real‐world benefit remain limited.
Paul Schmidle, Tobias Lang, Sebastian Springenberg, Diego Calvopiña, Theresa Köhler, Valentina Getova, Ana‐Maria Gebing, Sonja Hetzer, Johanna Pierrone, Valentin Aebischer, Dieter Metze, Almut Böer‐Auer, Stephan Alexander Braun   +12 more
wiley   +1 more source

Quick assessment of quality‐of‐life in itch: An exploratory validation of the 5‐item pruritus life quality

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Chronic pruritus (CP) significantly impairs quality of life (QoL), but existing patient‐reported QoL tools are either not specific for CP or are very extensive. Patients and methods The 5‐item pruritus life quality (5PLQ, range: 5–25, 7‐day recall) was developed to assess key itch‐related QoL domains (sensory symptoms,
Claudia Zeidler, Simone Garcovich, Svetlana Bobko, Franz J. Legat, Andrey Lvov, Emilie Brenaut, Adam Reich, Esther Serra‐Baldrich, Laurent Misery, Jacek C. Szepietowski, Martin Dugas, Felix Aulenbacher, Pascale Salameh, Sonja Ständer, Manuel P. Pereira   +14 more
wiley   +1 more source

Knowledge, Attitudes, and Stigmatizing Beliefs About HIV/AIDS Among Dental Students: The Impact of Clinical Education Level

European Journal of Dental Education, EarlyView.
ABSTRACT Background Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) remain major global public health concerns. Oral lesions are often among the earliest manifestations of HIV, placing dentists at the forefront of early detection and management.
Tuğba Aydoğdu, Berkant Sezer
wiley   +1 more source

Transmembrane MUC1 assists oral microbial colonization in oral mucosa of potentially malignant disorders and oral squamous carcinoma

European Journal of Oral Sciences, EarlyView.
Abstract Transmembrane mucin 1 (tMUC1) provides oral mucosal barrier against pathogens. The invasion of oncopathogenic microbes can promote cancerous proliferation of cells via inflammatory responses, abnormal cellular signaling, angiogenesis, anti‐adhesion, and tumorigenesis.
Lauriina Soiniemi, Matias Kanniainen, Saga Ramsay, Arja Kullaa, Bina Kashyap   +4 more
wiley   +1 more source