Comparative Conformational Sampling of Apo Adenylate Kinase by Enhanced Molecular Dynamics and a Sequence-Based Generative Ensemble Model. [PDF]
MoleculesZhao Q, Cui T, Li Y.
europepmc +1 more source
Floral traits and hermaphrodite abundance shape female advantage in a gynodioecious plant
American Journal of Botany, EarlyView.Abstract Premise Gynodioecy is maintained through female advantage in seed fitness that depends on the sex ratio of a population. We hypothesized that females of Silene acaulis would exhibit floral traits associated with elevated outcross pollination and that sex ratio would impact pollen limitation and inbreeding depression such that female advantage ...
Emma K. Chandler, Megan L. DeMarche
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Biallelic PAX6 Variants in an Adult With Severe Microphthalmia and Preserved Intellectual Function
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT PAX6 encodes a dosage‐sensitive transcription factor that is essential for eye development. Heterozygous PAX6 disease is well characterized, but biallelic disease is extremely rare and has been associated with anophthalmia, severe brain malformations, and perinatal lethality.
Karl De Geer +4 more
wiley +1 more source
Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont
Angewandte Chemie, EarlyView.Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley +11 more
wiley +2 more sources
Ultraviolet-C Light Emitter as a Method for Reducing Bacterial Contamination of Ophthalmic Instruments. [PDF]
J OphthalmolVelez-Montoya R +6 more
europepmc +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Van Maldergem syndrome (VMLDS) is an ultra‐rare autosomal recessive disorder characterized by craniofacial dysmorphism, intellectual disability, hypotonia, skeletal anomalies, and feeding difficulties. It is caused by biallelic variants in DCHS1 or FAT4 genes.
Gabriela Roldão Correia‐Costa +4 more
wiley +1 more source
Levodopa-induced dyskinesia provokes inflexible head-pelvis coordination during standing in Parkinson's disease. [PDF]
Clin Biomech (Bristol)Aderonmu JA, Dotov D, Curtze C.
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American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen +5 more
wiley +1 more source
Interference of iron deficiency in glycated hemoglobin testing and its clinical implications: a systematic review and meta-analysis. [PDF]
Biochem Med (Zagreb)Souza EMC, Domingueti CP.
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