Results 31 to 40 of about 687,930 (288)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Distinct Cytokine Profiles Correlate with Disease Severity and Outcome in Longitudinal Studies of Acute Hepatitis B Virus and Hepatitis D Virus Infection in Chimpanzees

mBio, 2020
Historical studies conducted in chimpanzees gave us the opportunity to investigate the basis for the different severities of liver damage and disease outcome associated with infection with wild-type hepatitis B virus (HBV) versus a precore HBV mutant ...
Ronald E. Engle, Davide De Battista, Emily J. Danoff, Hanh Nguyen, Zhaochun Chen, Paolo Lusso, Robert H. Purcell, Patrizia Farci   +7 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

شبیه‌سازی رواناب سطحی شهری و اولویت‌بندی روش‌های توسعه‌کم‌اثر با استفاده از مدل SWMM (مطالعه موردی: شهر نیشابور) [PDF]

مدیریت آب و آبیاری
اخیرا تغییر خصوصیات هیدرولوژیک و پاسخ حوضه شهری نسبت به بارش و سیلاب‌ها از نظر کمی و کیفی در زندگی بشر و منابع مشهودتر شده است. جلوگیری از اتلاف این هرزآب‌ها و به تبع آن جبران کمبود منابع‌آبی،‌ گامی موثر در این خصوص است.
اسماعیل حصاری, علی‌محمد آخوندعلی, محمدامین مداح   +2 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

A randomized crossover study of the effect of butorphanol–lidocaine and tramadol–lidocaine on sevoflurane's minimum alveolar concentration in dogs

Frontiers in Veterinary Science, 2023
Inhalational anesthesia is routinely used in small animal surgery. Selecting a suitable drug combination is vital since it may negatively affect the patient's physiological condition.
Mohamed Marzok, Mohamed Marzok, Adel I. Almubarak, Mahmoud Kandeel, Mahmoud Kandeel, Wael El-Deeb, Wael El-Deeb, Hussein Babiker, Sayed Fathi El-Hawari, Sayed Fathi El-Hawari   +9 more
doaj   +1 more source

Locally identifying coloring in bounded expansion classes of graphs [PDF]

, 2012
A proper vertex coloring of a graph is said to be locally identifying if the sets of colors in the closed neighborhood of any two adjacent non-twin vertices are distinct.
Gonçalves, Daniel, Parreau, Aline, Pinlou, Alexandre   +2 more
core   +7 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Ambivalent effects of added layers on steady kinematic dynamos in cylindrical geometry: application to the VKS experiment

, 2005
The intention of the ''von Karman sodium'' (VKS) experiment is to study the hydromagnetic dynamo effect in a highly turbulent and unconstrained flow. Much effort has been devoted to the optimization of the mean flow and the lateral boundary conditions in
Chiffaudel, A., Daviaud, F., Gerbeth, G., Léorat, J., Ravelet, F., Stefani, F., Xu, M.   +6 more
core   +3 more sources

Boussinesq/Boussinesq systems for internal waves with a free surface, and the KdV approximation [PDF]

, 2011
We study here some asymptotic models for the propagation of internal and surface waves in a two-fluid system. We focus on the so-called long wave regime for one dimensional waves, and consider the case of a flat bottom.
Benjamin, Benjamin, Besse, Besse, Bona, Bona, Bona, Boussinesq, Boussinesq, Chazel, Choi, Colliander, Craig, Craig, Djordjevic, Duchêne, Funakoshi, Grimshaw, Guyenne, Kakutani, Kato, Kenig, Keulegan, Koop, Korteweg, Lannes, Leone, Long, Matsuno, Michallet, Michallet, Ono, Ostrovsky, Sakai, Schneider, Segur, Vincent Duchêne, Walker, Zakharov   +38 more
core   +3 more sources