Results 91 to 100 of about 140,746 (300)

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Evaluation of Intravenous Lidocaine Overdose in Chickens (Gallus domesticus) [PDF]

Iranian Journal of Veterinary Surgery, 2013
Objective- To evaluate the total toxic dose of lidocaine and serum lidocaine concentrations resulting in clinical signs of toxicity in chickens. Design- Experimental study Animals- Eight healthy, female, 55-week-old chickens (Lohman breed) weighing 1.45 ±
Hadi Imani, Nasser Vesal, Soliman Mohammadi-Samani   +2 more
doaj  

Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]

, 2008
Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Ahern, Christopher A., Dougherty, Dennis A., Eastwood, Amy L., Horn, Richard   +3 more
core   +2 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Effects of Buffering and Preparation Time of Topical Anesthetics on Pain of Injection into Oral Mucosa

مجله دانشکده پزشکی اصفهان, 2012
Background: Many dental patients are afraid of injections. There are different methods for reducing pain during topical anesthetic injections. Some studies have reported buffering lidocaine to reduce injection pain.
Nasser Kaviani, Mojtaba Rahimi, Sayed Morteza Heidari, Zahra Rahmani   +3 more
doaj  

Effect of lidocaine on salicylate-induced tinnitus in guinea pigs: A focus on the auditory cortex.

PLoS ONE
This study aimed to investigate the effects of the intravenous administration of lidocaine in the auditory cortex after the systemic administration of salicylate. Healthy male albino Hartley guinea pigs were divided into two groups.
Mutsumi Kenmochi, Kentaro Ochi, Hirotsugu Kinoshita, Shigeru Kasugai, Manabu Nakamura, Manabu Komori   +5 more
doaj   +1 more source

Evaluation of Analgesic Effect of Caudal Epidural Tramadol, Tramadol-Lidocaine, and Lidocaine in Water Buffalo Calves (Bubalus bubalis)

Veterinary Medicine International, 2015
Aim of this study was to compare the analgesic effect of tramadol and a combination of tramadol-lidocaine with that produced by lidocaine administration in the epidural space in buffalo calves.
Ayman Atiba, Alaa Ghazy, Naglaa Gomaa, Tarek Kamal, Mustafa Shukry   +4 more
doaj   +1 more source

Effect of meloxicam and lidocaine administered alone or in combination on indicators of pain and distress during and after knife castration in weaned beef calves.

PLoS ONE, 2018
To assess the effect of meloxicam and lidocaine on indicators of pain associated with castration, forty-eight Angus crossbred beef calves (304 ± 40.5 kg of BW, 7-8 months of age) were used in a 28 day experiment.
Daniela M Meléndez, Sonia Marti, Edmond A Pajor, Pritam K Sidhu, Désirée Gellatly, Diego Moya, Eugene D Janzen, Johann F Coetzee, Karen S Schwartzkopf-Genswein   +8 more
doaj   +1 more source

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source

HLA genotype testing for carbamazepine, oxcarbazepine and eslicarbazepine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Carbamazepine is licensed in the United Kingdom for the treatment of epilepsy, bipolar disorder and trigeminal neuralgia. The related compounds oxcarbazepine and eslicarbazepine are licensed for the treatment of epilepsy. These drugs can cause immune‐mediated hypersensitivity reactions, which typically affect the skin, and can be of variable severity ...
Lucy Galloway, Cinzia Dello Russo, Nicholas Bass, Elvira Bramon, Helen Cross, Natalie Curley, Sarah Curran, Helen Davies, Jana De Villiers, William Evans, Bernhard Frank, Alice Groves, Judith Hayward, Jon Higham, Dyfrig A. Hughes, Shwe Sin Kyaw, Anthony G. Marson, Ailsa McLellan, Seth Mensah, Francis O'Neill, Jane Sargison, Sanjay M. Sisodiya, Jill Swan, Joanna M. Zakrewska, Munir Pirmohamed   +24 more
wiley   +1 more source