A Systematic Review of Laboratory Evidence for the Abuse Potential of Tramadol in Humans
Frontiers in Psychiatry, 2019 Background: Tramadol is an opioid-analgesic that has shown epidemiological evidence of abuse. This review evaluates the evidence for tramadol abuse potential in humans.Methods: A systematic literature search for human abuse liability examinations of ...
Kelly E Dunn +2 more
exaly +3 more sources
Tramadol Poisoning: A Systematic Review of Studies in Iran
International Journal of Medical Toxicology and Forensic Medicine, 2021 Background: According to statistics, tramadol use is extremely prevalent in Iran. Besides, tramadol overdose is mostly observed in young individuals. Given the significance of this issue and the increasing prevalence of tramadol use in Iran, this study ...
Reza Akhavan +6 more
doaj +1 more source
ASSESSMENT OF TRAMADOL BLOOD CONCENTRATION IN CASES OF ACUTE TRAMADOL OVERDOSE [PDF]
The Egyptian Journal of Forensic Sciences and Applied Toxicology, 2020 Tramadol is a synthetic analgesic drug that has been used for acute and chronic pain. It has a potential risk of addiction and overdoses due to its common illegal abuse.
Mahmoud Abd El wahab, Hany Tawfik
doaj +1 more source
Ameliorative Effect of Nigella Sativa on Tramadol-Induced Testicular Toxicity in Adult Rats [PDF]
Egyptian Society of Clinical Toxicology Journal, 2022 Background: Tramadol abuse is a major health problem in Egypt. It promotes oxidative stress via lowering the antioxidant levels. Nigella sativa (NS) possesses strong antioxidant properties.
Reham Eldemerdash Ibrahim +3 more
doaj +1 more source
Comparison of tramadol, lidocaine and tramadol-lidocaine combination for epidural analgesia in goats [PDF]
Journal of Veterinary Medical Research, 2017 The aim of this study was to compare the analgesic effect of tramadol, lidocaine and tramadol-lidocaine combination injected in the epidural space in goats.
Ragab G. H., Seif M. M, Fatma M. Halfaya
doaj +2 more sources
Effects of the Concomitant Administration of Thyme and Tramadol on the Cerebellar Cortex of Adult Male Albino Rat [PDF]
The Egyptian Journal of Histology, 2023 Introduction: Tramadol is a centrally acting opioid analgesic that used to relief pain. Although tramadol is thought to have low dependence potentials, it is used in acute or chronic pain, including postoperative, gynecologic and obstetric pain, as well ...
Mohamed Mohamed +3 more
doaj +1 more source
Brazilian Journal of Anesthesiology, 2015 Background and objectives: Tramadol is known as a central acting analgesic drug, used for the treatment of moderate to severe pain. Local analgesic effect has been demonstrated, in part due to local anesthetic-like effect, but other mechanisms remain ...
Angela Maria Sousa, Hazem Adel Ashmawi
doaj +3 more sources
Tramadol Treatment Induces Change in Phospho-Cyclic Adenosine Monophosphate Response Element-Binding Protein and Delta and Mu Opioid Receptors within Hippocampus and Amygdala Areas of Rat Brain [PDF]
Addiction and Health, 2021 Background: Tramadol induces its unique effects through opioid pathways, but the exact mechanism is not known. The study aims to evaluate changes in the level of mu-opioid receptor (μOR), delta-opioid receptor (δOR), and phosphorylated cyclic adenosine ...
Hamid Ahmadian-Moghadam +5 more
doaj +1 more source
Histological and Immunohistochemical Study on the Effect of Tramadol Abuse on Cerebral Cortex and Hippocampus in Male Albino Rabbits [PDF]
The Egyptian Journal of Histology, 2020 Background: Tramadol is an analgesic used in moderate and severe pain however, tramadol abuse among adolescence leads to various alterations in brain histological structure that leads to psychiatric and physical abnormalities.Aim of the Work: This study ...
Hanan Elkerdasy, nehal shaheen
doaj +1 more source
Factors Affecting Tramadol-Associated Seizure
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Tramadol is a widely prescribed analgesic and due to its opioid-like effects, the potential for abuse of tramadol is noticeable. Besides, the complications of tramadol abuse have become a public health concern. This study aimed to investigate
Maryam Zaare Nahandi +4 more
doaj +1 more source