Results 21 to 30 of about 68,585 (257)
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
core +1 more source
Post-mortem toxicology: A pilot study to evaluate the use of a Bayesian network to assess the likelihood of fatality [PDF]
, 2015 The challenge of interpreting post-mortem drug concentrations is well documented and relies on appropriate sample collection, knowledge of case circumstances as well as reference to published tables of data, whilst taking into account the known issues of
Bolton, Jennifer +3 more
core +1 more source
PLoS ONE, 2021 BackgroundAlthough tramadol is an effective weak opioid analgesic, careful monitoring of potential central nervous system adverse reactions in older adults is needed, especially when used with concomitant medications which may trigger the adverse effects.
Bo Ram Yang +4 more
doaj +1 more source
Intertarsal Joint Stabilization in a Bateleur Eagle (Terathopius ecaudatus) Using a Novel Application of a Braided Suture and Titanium Button System. [PDF]
, 2017 A 32-year-old adult captive male bateleur eagle (Terathopius ecaudatus) with a history of laxity, degenerative joint disease, and varus deviation of the distal left hindlimb for several years was presented for evaluation of left hindlimb lameness and was
De Voe, Ryan S +3 more
core +2 more sources
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Tikrit Journal of Pure Science, 2023 The aim of study to determine out the role of CoQ10 in reducing the side effects from the use of Tramadol on the level of Interlukin IL-6, IL-10 and PGF2α the study included 30 endemic female rabbits, where each group included 5 animals.
Hanan Shihab Ahmad Hussain +2 more
doaj +1 more source
Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo [PDF]
, 2014 A new working hypothesis of Parkinson's disease (PD) proposes to focus on the central role of entropy increase in the basal ganglia (BG) in movement disorders. The conditions necessary for entropy increase in vivo are, however, still not fully described.
Andres, Daniela Sabrina +3 more
core +3 more sources
Frontiers in Pharmacology, 2021 Background: Most studies examining tramadol metabolism have been carried out in non-surgical patients and with oral tramadol. The aim of this study was 1) to measure concentrations of tramadol, O-demethyltramadol (ODT), and N-demethyltramadol (NDT) in ...
Nenad Neskovic +16 more
doaj +1 more source
Pharmacogenetics of analgesic drugs [PDF]
, 2013 • Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R +4 more
core +1 more source