Results 31 to 40 of about 30,088 (226)

Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children

British Journal of Clinical Pharmacology, EarlyView.
Codeine is commonly used in combination analgesic products. The use of codeine during breastfeeding can rarely be associated with serious adverse effects related to genetic polymorphisms affecting codeine's metabolism and disposition. Clinicians treating infants of breastfeeding mothers should be aware of this rare but potentially serious complication.
Michael Rieder
wiley   +1 more source

Impact of parameter settings on the estimation of drug exposure with the individualized dispensing patterns method

British Journal of Clinical Pharmacology, EarlyView.
Aim To assess the impact of parameter settings when using the individualized dispensing patterns (IDP) method to estimate exposure duration from dispensing data. Methods We conducted a cohort study using a 2% representative sample of the French healthcare insurance database from 2013 to 2022.
Laëtitia Gosselin, Clara Lévy, Noémie Sève, Thierry Blanchon, Marianne Sarazin, Louise Rossignol, Maryse Lapeyre‐Mestre, Nathanaël Lapidus, Olivier Steichen   +8 more
wiley   +1 more source

Exploring the potential use of melatonin as a modulator of tramadol-induced rewarding effects in rats

Frontiers in Pharmacology
Background:Melatonin is responsible for regulating the sleep-wake cycle and circadian rhythms in mammals. Tramadol, a synthetic opioid analgesic, is used to manage moderate to severe pain but has a high potential for abuse and dependence.
Alqassem Y. Hakami, Alqassem Y. Hakami, Badrah S. Alghamdi, Badrah S. Alghamdi, Fahad S. Alshehri   +4 more
doaj   +1 more source

Effects of Dependence of Tramadol, Diazepam and Their Combination on the Brain of Albino Rats: Biochemical, Histological and Immunohistochemical Study [PDF]

Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2014
Introduction: Nowadays tramadol is the most common drug of abuse. Egyptian surveys found a gradual increase in the use of tramadol among Egyptians. It has been associated with a wide range of drug abuse such as benzodiazepines.
Hayam Aiad, Reham Mohamed, Azza Zanaty, Safaa Amin, Samy Hammad, Samy Badawy   +5 more
doaj   +1 more source

The impact of medication shortages on paediatric care: A retrospective impact analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Medication shortages are a growing global concern, with potentially greater consequences in paediatric patients because of the limited availability of safe, evidence‐based and appropriately formulated medication. This study aimed to evaluate the impact of medication shortages on paediatric patients by assessing the suitability and safety of ...
Maaike Johanna Rutten ‐ van Kranenburg, Laurens Christiaan van Rijn, Elisabeth Johanna Ruijgrok, Sinno Henricus Paulus Simons, Brigitta Carolina Maria Witjes, Jan‐Dietert Christoffer Brugma, Robert Bernard Flint   +6 more
wiley   +1 more source

Patterns and social factors associated with non-prescription use of Tramadol: a cross-sectional study among youth in urban informal settlements in Ghana

Journal of Health, Population and Nutrition
Background Non-prescription use of Tramadol is increasingly becoming common among vulnerable populations. This study examines the factors associated with non-prescription use of Tramadol among youth in urban informal settlements in the Asokore Mampong ...
Solomon Osei-Tutu, Felix Asante, Williams Agyemang-Duah, Obed Jones Owusu-Sarpong, Lawrencia Pokuah Siaw, Razak M. Gyasi   +5 more
doaj   +1 more source

Different Pharmacokinetics of Tramadol, O-Demethyltramadol and N-Demethyltramadol in Postoperative Surgical Patients From Those Observed in Medical Patients

Frontiers in Pharmacology, 2021
Background: Most studies examining tramadol metabolism have been carried out in non-surgical patients and with oral tramadol. The aim of this study was 1) to measure concentrations of tramadol, O-demethyltramadol (ODT), and N-demethyltramadol (NDT) in ...
Nenad Neskovic, Nenad Neskovic, Dario Mandic, Dario Mandic, Saska Marczi, Saska Marczi, Sonja Skiljic, Sonja Skiljic, Gordana Kristek, Gordana Kristek, Hrvoje Vinkovic, Hrvoje Vinkovic, Boris Mraovic, Zeljko Debeljak, Zeljko Debeljak, Slavica Kvolik, Slavica Kvolik   +16 more
doaj   +1 more source

Understanding Consumption of Illicit Drugs and New Psychoactive Substances in Australia by Triangulating Drug Checking and Wastewater‐Based Epidemiology

Drug Testing and Analysis, EarlyView.
First Australian study combining wastewater‐based epidemiology and drug checking, demonstrating how complementary data sources enhance monitoring of illicit drugs and emerging psychoactive substances during high‐use periods. ABSTRACT Consumption of psychotropic drugs is a major economic and public health challenge in Australia.
Muhammad Usman, Malcolm McLeod, Dhayaalini Nadarajan, Joseph Clokey, Pritesh Prasad, Rory Verhagen, Benjamin Tscharke, Maurizio Quinto, Richard Bade   +8 more
wiley   +1 more source

A comparative study of postmortem distribution and postmortem diffusion of tramadol in rabbits

Scientific Reports, 2023
In recent years, the cases of tramadol intoxication have become more frequent in many countries. However, most of the previous studies have been based on cases of tramadol intoxication, and the detailed information on the differences between postmortem ...
Hongliang Su, Lingxiao Wang, Amin Wurita, Chao Zhang, Miaomiao Wu, Bin Li, Weifen Niu, Youmei Wang, Zhiwen Wei, Keming Yun   +9 more
doaj   +1 more source

“Here in Ghana hard work don’t deserve money”: The uncertainty and precarity of youth who use tramadol

SSM: Qualitative Research in Health, 2022
There has been a global rise in problematic non-medical use of prescription medication. In West Africa, recent media reports have highlighted increases in the use of tramadol especially among youth. In Ghana, current framings of this issue have described
Jacob Albin Korem Alhassan
doaj   +1 more source