Results 41 to 50 of about 37,856 (275)
Effects of Dependence of Tramadol, Diazepam and Their Combination on the Brain of Albino Rats: Biochemical, Histological and Immunohistochemical Study [PDF]
Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2014 Introduction: Nowadays tramadol is the most common drug of abuse. Egyptian surveys found a gradual increase in the use of tramadol among Egyptians. It has been associated with a wide range of drug abuse such as benzodiazepines.
Hayam Aiad +5 more
doaj +1 more source
Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children
British Journal of Clinical Pharmacology, EarlyView.Codeine is commonly used in combination analgesic products. The use of codeine during breastfeeding can rarely be associated with serious adverse effects related to genetic polymorphisms affecting codeine's metabolism and disposition. Clinicians treating infants of breastfeeding mothers should be aware of this rare but potentially serious complication.
Michael Rieder
wiley +1 more source
Journal of Health, Population and NutritionBackground Non-prescription use of Tramadol is increasingly becoming common among vulnerable populations. This study examines the factors associated with non-prescription use of Tramadol among youth in urban informal settlements in the Asokore Mampong ...
Solomon Osei-Tutu +5 more
doaj +1 more source
Frontiers in PharmacologyBackground:Melatonin is responsible for regulating the sleep-wake cycle and circadian rhythms in mammals. Tramadol, a synthetic opioid analgesic, is used to manage moderate to severe pain but has a high potential for abuse and dependence.
Alqassem Y. Hakami +4 more
doaj +1 more source
Potential for Tramadol Abuse by Patients Visiting Pharmacies in Northern Iran
, 2011 Background It has been almost three decades since tramadol was introduced to the market as a centrally acting analgesic. It is claimed to have weak opioid properties and a low dependence potential in opioid-addicted patients.
Baradaran Mahmoud +5 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit +7 more
wiley +1 more source
Segmental Hair Analysis of Diphenhydramine and Cyclizine Following a Single Dose
Drug Testing and Analysis, EarlyView.A single oral dose of diphenhydramine and cyclizine can be quantified in human head hair for a minimum of 5 months and, in certain cases, for up to 1 year following intake. Among 12 study participants, the measured concentrations ranged from 0 to 610 pg/mg within 1 year post‐intake.
Jan Bílek +3 more
wiley +1 more source
Advanced Biomedical Research, 2022 Background: Tramadol is an opioid analgesic with monoamine reuptake inhibitory effects. Although tramadol has been widely used to control pain, there is controversy about the risk of abuse.
Neda Hasanpour Razmanjani, Parham Reisi
doaj +1 more source
British Journal of Anaesthesia, 1998 The lack of analgesic efficacy limits tramadol as a sole agent to treat severe pain after surgery. However, it has a relative lack of respiratory depressant and constipating effects compared with morphine and codeine, and does not share the propensity of nonsteroidal anti-inflammatory drugs to provoke asthma, gastrointestinal mucosal damage and renal ...
openaire +2 more sources
Drug Testing and Analysis, EarlyView.Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp +6 more
wiley +1 more source