Results 111 to 120 of about 195,574 (320)

Setting up mother–infant pair lactation studies with biobanking for research according to regulatory requirements

British Journal of Clinical Pharmacology, EarlyView.
Within the ConcePTION project we set out to design two mother–infant pair studies collecting breast milk and plasma from the mother and plasma from the infant (for metformin and prednisolone) in order to demonstrate the premises and conditions for investigating potential drug transfer in association with breastfeeding.
Mats Hansson, Ida Björkgren, Jenny Svedenkrans, Helena Backman, Jarl Hellman, Linda Englund‐Ögge, Mikaela Magnusson, Inger Lindström, Andrea Wutte, Erica Sundell, Pawel Baranczewski, Laura Shaughnessy   +11 more
wiley   +1 more source

On the Job: Tina Nichols [PDF]

, 2017
As Office Supervisor in the Division of Transplant Surgery, Tina Nichols spends her days tackling a variety of time-sensitive tasks – from setting up meetings and working on provider credentialing to sorting out billing issues and scheduling patients for

core   +1 more source

Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]

, 2016
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia, Brock, Mathew, Chan, Dulciana, Chvatal, Stacie, Crumb, William J., Galeotti, Loriano, Hortigon-Vinagre, Maria P., Johannesen, Lars, Lyn-Cook, Beverly, Millard, Daniel, Pang, Li, Ross, James, Smith, Godfrey, Stockbridge, Norman, Stohlman, Jayna, Strauss, David G., Vicente, Jose, Zamora Rodriguez, Victor   +17 more
core   +1 more source

HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death

Scientific Reports, 2017
The local anesthetic lidocaine induces cell death by altering reactive oxygen species (ROS) generation and mitochondrial electron transport chain function.
A. Okamoto, C. Sumi, Hiromasa Tanaka, Munenori Kusunoki, Teppei Iwai, K. Nishi, Y. Matsuo, H. Harada, K. Takenaga, H. Bono, K. Hirota   +10 more
semanticscholar   +1 more source

All Organisms Can Be Anesthetized, but There's No Point?

BioEssays, EarlyView.
ABSTRACT Because of their interest in medicine, most studies on anesthesia have historically focused on the nervous systems of animals. This has often led to the neglect of the fact that all life forms have the potential to be anesthetized. Anesthetics target proteins, such as four‐domain voltage‐dependent Na+/Ca2⁺ channels (4D‐NaV/CaV) and glutamate ...
Lucia Sylvain‐Bonfanti, Delphine Arbelet‐Bonnin, Christophe Lalanne, Olivier Dellis, Patrice Meimoun, Patrick Laurenti, Etienne Grésillon, François Bouteau   +7 more
wiley   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Time Course of the Soleus M Response and H Reflex after Lidocaine Tibial Nerve Block in the Rat

The Scientific World Journal, 2013
Aims. In spastic subjects, lidocaine is often used to induce a block predictive of the result provided by subsequent surgery. Lidocaine has been demonstrated to inhibit the Hoffmann (H) reflex to a greater extent than the direct motor (M) response ...
Kévin Buffenoir, Philippe Decq, Chantal Pérot   +2 more
doaj   +1 more source

Management of post‐implant fibrous dysplasia in the maxilla: A case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Fibrous dysplasia is generally rare, and even rarer in older adults. Special care is needed when altering the alveolar bone in these cases, especially if an implant is involved. This case study highlights such a scenario. Methods This case study details the experience of a 63‐year‐old African American female who presented with a ...
Yousef Taha Y. Amrou, Anass M. Koleilat, Abdusalam E. Alrmali, Felipe Nor, Hom‐Lay Wang   +4 more
wiley   +1 more source

Topical analgesia for acute otitis media [PDF]

, 2006
BACKGROUND: Acute otitis media (AOM) is a spontaneously remitting disease for which pain is the most distressing symptom. Antibiotics are now known to have less benefit than previously assumed.OBJECTIVES: To assess the effectiveness of topical analgesia ...
Del Mar, C, Dooley, L, Foxlee, R, Johansson, A, Wejfalk, J   +4 more
core   +1 more source

Crestal approach for repair of oroantral bone defects and subsequent implant placement

Clinical Advances in Periodontics, EarlyView.
Abstract Background Oroantral communication (OAC) can occur after a dental extraction. Occasionally, bony defects may persist despite successful soft tissue closure of the OAC. The absence of bone in these areas poses challenges for dental implant placement.
Min Yang, Miriam Ting, Rodrigo Neiva, Jonathan Korostoff   +3 more
wiley   +1 more source