Results 11 to 20 of about 204,403 (390)
Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer
Frontiers in Pharmacology, 2021 Ovarian and breast cancer are prevalent female malignancies with increasing occurrence incidence and metastasis, significantly affecting the health and life quality of women globally.
Dan Sun, Ying-Chun Li, Xiao-Yu Zhang
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Artificial Cells, Nanomedicine, and Biotechnology, 2019 Background Despite the medical uses of lidocaine has been well-characterized, the study of lidocaine’s pharmacological function other the anaesthetic effect was never stopped.
Hai Sun, Yan Sun
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Journal of Clinical Medicine, 2023 There has recently been increasing evidence that the use of perioperative intravenous lidocaine infusion possesses analgesic, opioid-sparing and anti-inflammatory effects in surgical patients.
Irene Castro +4 more
semanticscholar +1 more source
Cancers, 2021 Simple Summary The local anesthetic lidocaine suppresses some cancer cell lines but the mechanism is unclear. Melastatin-like transient receptor potential 7 (TRPM7) ion channels play a role in cancer and may be a target for lidocaine.
Hengrui Liu, J. Dilger, Jun Lin
semanticscholar +1 more source
Topical Lidocaine for Chronic Pain Treatment
Drug Design, Development and Therapy, 2021 Topical lidocaine is widely used in current practice for a variety of pain conditions. This literature review shows that its limited absorption and relative lack of systemic adverse events are an attractive analgesic option for a number of vulnerable ...
Marion Voute, V. Morel, G. Pickering
semanticscholar +1 more source
Anaesthesia, 2020 Intravenous lidocaine is used widely for its effect on postoperative pain and recovery but it can be, and has been, fatal when used inappropriately and incorrectly. The risk‐benefit ratio of i.v.
I. Foo +7 more
semanticscholar +1 more source
A review of the mechanism of the central analgesic effect of lidocaine
Medicine, 2020 Lidocaine, as the only local anesthetic approved for intravenous administration in the clinic, can relieve neuropathic pain, hyperalgesia, and complex regional pain syndrome. Intravenous injection of lidocaine during surgery is considered as an effective
Xi Yang +4 more
semanticscholar +1 more source
Utility of lidocaine as a topical analgesic and improvements in patch delivery systems
Postgraduate medicine, 2020 Interest in and use of topical analgesics has been increasing, presumably due to their potential utility for relief of acute and chronic pain. Topically applied agents with analgesic properties can target peripheral nociceptive pathways while minimizing ...
J. Gudin, S. Nalamachu
semanticscholar +1 more source
Development of Lidocaine-Loaded Dissolving Microneedle for Rapid and Efficient Local Anesthesia
Pharmaceutics, 2020 Lidocaine is a local anesthetic agent used in the form of injection and topical cream. However, these formulation types have limitations of being either painful or slow-acting, thereby hindering effective and complete clinical performance of lidocaine ...
Huisuk Yang +12 more
semanticscholar +1 more source
Cancer Medicine, 2020 Lidocaine, one of the most commonly used local anesthetics during surgery, has been reported to suppress cancer cell growth via blocking voltage‐gated sodium channels (VGSCs).
Chang Liu +9 more
semanticscholar +1 more source