Capsazepine prolongation of the duration of lidocaine block of sensory transmission in mice may be mediated by modulation of HCN channel currents [PDF]
PeerJ, 2019 Background and objectives Hyperpolarization-activation cyclic nucleotide-gated (HCN) channels contribute to the effects of lidocaine. Capsazepine (CPZ), a competitive inhibitor of capsaicin of transient receptor potential vanilloid-1 channel, has also ...
Wenling Zhao +7 more
doaj +2 more sources
Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest.
New England Journal of Medicine, 2016 BACKGROUND Antiarrhythmic drugs are used commonly in out-of-hospital cardiac arrest for shock-refractory ventricular fibrillation or pulseless ventricular tachycardia, but without proven survival benefit. METHODS In this randomized, double-blind trial,
P. Kudenchuk +26 more
semanticscholar +1 more source
Lidocaine inhibits osteogenic differentiation of human dental pulp stem cells
Journal of International Medical Research, 2023 Objective Lidocaine is an amide local anaesthetic commonly used for pain control, however, few studies have investigated the effect of lidocaine on the osteogenic differentiation of human dental pulp stem cells (HDPSCs).
Eun-Jung Kim +6 more
doaj +1 more source
Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart [PDF]
, 2009 Heart valve anomalies are some of the most common congenital heart defects, yet neither the genetic nor the epigenetic forces guiding heart valve development are well understood.
A. C Oates +60 more
core +3 more sources
A novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia: An in vitro study [PDF]
Archives of Biological SciencesThis study investigated the efficacy of a novel lidocaine-chitosan-barium titanate microemulsion gel for prolonged local anesthesia. The lidocaine microemulsion comprised 5% (w/w) lidocaine, linoleic acid (LA), chitosan, barium titanate (BaTiO3 ...
Qiao Xiaoru, Li Ling
doaj +1 more source
Molecular mechanisms of lidocaine
Annals of Medicine & Surgery, 2021 Lidocaine is an amide-class local anesthetic used clinically to inhibit pain sensations. Systemic administration of lidocaine has antinociceptive, antiarrhythmic, anti-inflammatory, and antithrombotic effects. Lidocaine exerts these effects under both acute and chronic pain conditions and acute respiratory distress syndrome through mechanisms that can ...
Resiana Karnina +3 more
openaire +2 more sources
International Journal of Nanomedicine, 2019 Aim To develop the topical gel containing transferosomal lidocaine as alternative to painful local anesthetic injection. Materials and methods The transfersomes were prepared by film hydration technique using soybean phosphatidylcholine and cholesterol ...
M. Omar +2 more
semanticscholar +1 more source
Conditioned place preference reveals ongoing pain in calves 3 weeks after disbudding. [PDF]
, 2020 Hot-iron disbudding, a routine procedure that prevents horn bud growth through cauterization, is painful for calves. The resulting burns remain sensitive to touch for weeks, but it is unknown whether calves experience ongoing, non-evoked pain.
Adcock, Sarah JJ, Tucker, Cassandra B
core
Intracameral lidocaine as supplement to classic topical anesthesia for relieving ocular pain in cataract surgery [PDF]
, 2018 ● AIM: To evaluate safety, efficacy, and patient adherence of intracameral lidocaine as supplement of classic topical anesthetic drops in cataract surgery.
Librando, Aloisa +4 more
core +2 more sources
Cancers, 2019 Addressing the hypothesis that anaesthetic-analgesic technique during cancer surgery might influence recurrence or metastatic spread is a research priority.
J. Freeman +6 more
semanticscholar +1 more source