Results 41 to 50 of about 3,769 (264)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Structure of Primitive Leibniz Algebras via Maximal Subalgebras

Mathematics
In this paper, we investigate the structure of primitive Leibniz algebras via their maximal subalgebras and minimal ideals. Using a two-sided definition of the centraliser, we show that the centraliser of a minimal ideal is again an ideal. Unlike the Lie
Zekiye Çiloğlu Şahin
doaj   +1 more source

On generalized Lie derivations of Lie ideals of prime algebras

Linear Algebra and its Applications, 2009
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Liao, Ping-Bao, Liu, Cheng-Kai
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Rings with involution whose symmetric elements are central

International Journal of Mathematics and Mathematical Sciences, 1980
In a ring R with involution whose symmetric elements S are central, the skew-symmetric elements K form a Lie algebra over the commutative ring S. The classification of such rings which are 2-torsion free is equivalent to the classification of Lie ...
Taw Pin Lim
doaj   +1 more source

Lie Ideal Enhancements of Counting Invariants

Osaka Journal of Mathematics, 2014
We define enhancements of the quandle counting invariant for knots and links with a finite labeling quandle Q embedded in the quandle of units of a Lie algebra \mathfrak{a} using Lie ideals. We provide examples demonstrating that the enhancement is stronger than the associated unenhanced counting invariant.
Grindstaff, Gillian Roxanne, Nelson, Sam
openaire   +4 more sources

Lie Structures and Chain Ideal Lattices

Bulletin of the Brazilian Mathematical Society, New Series, 2023
AbstractThe purpose of this paper is twofold. Firstly, to emphasise that the class of Lie algebras with chain lattices of ideals are elementary blocks in the embedding or decomposition of Lie algebras with finite lattice of ideals. Secondly, to show that the number of Lie algebras of this class is large and they support other types of Lie structures ...
Benito, Pilar, Roldán-López, Jorge, 0000-0002-9106-8136   +2 more
openaire   +4 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source