Results 11 to 20 of about 1,641 (111)

An Integrated and Robust Deep Learning Framework for Denoising and Analyzing Single‐Cell Spatial Transcriptomics

Advanced Intelligent Systems, EarlyView.
Single‐cell Spatial Transcriptomics Analysis and Denoising Engine is introduced as a unified deep learning framework that jointly performs denoising, clustering, and gene prioritization in spatial transcriptomics. By integrating linear and nonlinear representations within a dual‐channel architecture, it improves robustness and accuracy, uncovers ...
Yaxuan Cui, Yang Cui, Ruheng Wang, Xin Zeng, Zheyong Zhu, Ding Yi, Ruihua Guo, Tetsuya Sakurai, Kenta Nakai, Xiucai Ye, Leyi Wei, Yong Chen   +11 more
wiley   +1 more source

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, EarlyView.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Multi‐method analysis for the three‐dimensional reconstruction of muscle fascicles from DiceCT datasets

The Anatomical Record, EarlyView.
Abstract Muscle architecture is a major determinant of muscle performance and, in mammalian lineages, has been correlated with both feeding ecology and locomotor behaviors. Over the past decade, contrast‐enhanced micro‐CT (DiceCT) has emerged as an alternative to traditional dissection‐based measurement.
Aleksandra Ratkiewicz, Michael C. Granatosky, Cassidy E. Davis, Julia Molnar, Adam Hartstone‐Rose, Edwin Dickinson   +5 more
wiley   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Pain at intrauterine device placement in a Brazilian center

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study explores pain at intrauterine device (IUD) placement in a large Brazilian cohort. Methods We undertook a cross‐sectional analysis of health records from individuals aged 18 to 45 years who underwent IUD placements between 2022 and 2024 at the Department of Obstetrics and Gynecology, Universidade Estadual de Campinas ...
Ana Luiza Savi, Judith Lieber, Cássia Raquel Teatin Juliato, Rachel Scott, Luis Bahamondes   +4 more
wiley   +1 more source

Synthesis and Characterization of an Azido Nitrofurazanyl Ether: An Energy‐Rich Heterocyclic Plasticizer With a Low Glass Transition Temperature

Propellants, Explosives, Pyrotechnics, EarlyView.
ABSTRACT We report on the synthesis and characterization of 3‐(2‐(2‐azidoethoxy)ethoxy)‐4‐nitro‐1,2,5‐oxadiazole (NFPEG2N3), which is a liquid nitrofurazanyl ether that was designed to be an energy‐rich plasticizer for glycidyl azide polymer (GAP)‐ and nitrocellulose (NC)‐based formulations.
P. Lieber, A. Omlor, U. Schaller, T. M. Klapötke   +3 more
wiley   +1 more source

Concurrent validity and agreement of Bayley‐4, AIMS, and HINE assessments in 1‐year‐old children

Developmental Medicine &Child Neurology, EarlyView.
In this cross‐sectional study of children around 1‐year‐old, the Bayley‐4 showed concurrent validity and moderate to substantial agreement with the AIMS and the HINE in both clinical and home settings. Abstract Aim To examine concurrent validity between the Bayley Scales of Infant and Toddler Development, Fourth Edition (Bayley‐4) gross motor subtest ...
Weiyang Deng, Bahda Hoang, Meaghan Rubsam, Gabriela Lopez, Megan K. O'Brien, Theresa Sukal‐Moulton, Barbara Sargent, Colleen Peyton, Elizabeth Hoffman, Samuel Carey, Nicole Pouppirt, Raye‐Ann de Regnier, John A. Rogers, Richard L. Lieber, Arun Jayaraman   +14 more
wiley   +1 more source

Hoffmann's two‐toed sloth II: Muscle architectural properties in the thoracic limb of Choloepus (Pilosa: Xenarthra)

Journal of Anatomy, EarlyView.
Two‐toed sloths use their thoracic limbs for more frequent and greater suspensory support than three‐toed sloths and have muscle architectural properties consistent with stability of the pectoral girdle, enhanced flexor force/torque applied at the shoulder and elbow joints, and grip on the support as indicated by their myology. Abstract Two‐toed sloths
C. S. Tucker, A. M. Mossor, K. B. Spainhower, J. A. Avey‐Arroyo, M. T. Butcher   +4 more
wiley   +1 more source

Scratching beneath the surface: Quantification of muscle architecture and myosin heavy chain content in the forelimbs of black‐tailed prairie dogs (Cynomys, Rodentia)

Journal of Anatomy, EarlyView.
Black‐tailed prairie dogs are highly social ground squirrels that excavate communal burrow systems, most often in medium‐textured soils. Their forelimbs demonstrate morphofunctional trade‐offs for scratch‐digging and terrestrial ecology, including well‐developed and fast‐contracting proximal musculature with large mechanical advantage paired with ...
Luke A. Scheetz, Carter A. Burnett, Benjamin R. Kimble, David A. Eads, Michael T. Butcher   +4 more
wiley   +1 more source

Functional morphology and biomechanics of the locomotor apparatus in the large Late Triassic carnivore Postosuchus kirkpatricki (Archosauria: Rauisuchidae)

Journal of Anatomy, EarlyView.
A three‐dimensional model is used to analyze the locomotor biomechanics of the large Late Triassic archosaurian reptile Postosuchus kirkpatricki. The study finds that it is more uncertain than previously concluded whether it was quadrupedal or bipedal, and plantigrade or digitigrade, but it clearly had locomotor specializations including large hindlimb
John R. Hutchinson, Emily Faughey, Matthew Humpage, Tristan Dupuis, Oliver E. Demuth, Romain Pintore, Francois Clarac   +6 more
wiley   +1 more source