Results 41 to 50 of about 14,717 (264)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Epistles from Jerusalem: The Paratexts of Syriac 2 Baruch and the Peshitta Jeremiah Corpus
Religions, 2022 This article explores the paratexts of the epistles attributed to Baruch, the scribe of Jeremiah, in Syriac, Peshitta Old Testament manuscripts. In early manuscripts, the epistles ascribed to the figure Baruch are, most commonly, either included in the ...
Liv Ingeborg Lied
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Appressorium: The Breakthrough in Dikarya
Journal of Fungi, 2019 Phytopathogenic and mycorrhizal fungi often penetrate living hosts by using appressoria and related structures. The differentiation of similar structures in saprotrophic fungi to penetrate dead plant biomass has seldom been investigated and has been ...
Alexander Demoor +2 more
doaj +1 more source
HD_BPMDS: a curated binary pattern multitarget dataset of Huntington’s disease–targeting agents
Journal of Cheminformatics, 2023 The discovery of both distinctive lead molecules and novel drug targets is a great challenge in drug discovery, which particularly accounts for orphan diseases.
Sven Marcel Stefan +2 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Adapted or Adaptable: How to Manage Entropy Production?
Entropy, 2019 Adaptable or adapted? Whether it is a question of physical, biological, or even economic systems, this problem arises when all these systems are the location of matter and energy conversion.
Christophe Goupil, Eric Herbert
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Incontri: Rivista Europea di Studi Italiani, 2011 De literatuur ontmoet het liedIn dit artikel worden de bijdragen van de schrijvers Italo Calvino en Franco Fortini aan het Italiaanse lied besproken. Enkele van hun teksten werden op muziek gezet op initiatief van Cantacronache.
Sebastiano Ferrari
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Lies, Damned Lies, and Statistics
Journal of the American College of Cardiology, 2008 ![Figure][1] “Facts are stubborn things, but statistics are more pliable.” —Mark Twain ([1][2]) It has often been said in the halls of academia that physicians would have difficulty critically reading the medical literature if they had never done research themselves.
openaire +2 more sources