Results 51 to 60 of about 43,096 (294)

HD_BPMDS: a curated binary pattern multitarget dataset of Huntington’s disease–targeting agents

open access: yesJournal of Cheminformatics, 2023
The discovery of both distinctive lead molecules and novel drug targets is a great challenge in drug discovery, which particularly accounts for orphan diseases.
Sven Marcel Stefan   +2 more
doaj   +1 more source

Lies, Damned Lies, and Statistics

open access: yesJournal of the American College of Cardiology, 2008
![Figure][1] “Facts are stubborn things, but statistics are more pliable.” —Mark Twain ([1][2]) It has often been said in the halls of academia that physicians would have difficulty critically reading the medical literature if they had never done research themselves.
openaire   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Las rimas de Gustavo Adolfo Bécquer (Sevilla, 1836 – Madrid, 1870) en la canción lírica: una revisión bibliográfica

open access: yesMúsica Oral del Sur, 2019
El presente artículo gira en torno a la musicalización de las rimas de G. A. Bécquer en el género de la canción lírica, fenómeno desarrollado desde el último tercio del siglo XIX hasta nuestros días.
Candela Tormo Valpuesta
doaj  

QUELLE DIE SINGT [PDF]

open access: yesHum, 2009
Es ist die Rede von einer durch die Schönheit der Heimatslandschaft motivierenden Poesie wie überhaupt die Schönheit des Kosmos betreffend oder der Natur im Ganzen, in der „Logos, und nicht Kaos“ herrscht.
Šimun Musa
doaj  

STANESCU'S LYRICS IN THE CREATION OF COMPOSERS CORNEL ȚĂRANU AND DAN VOICULESCU [PDF]

open access: yesStudiul Artelor şi Culturologie: Istorie, Teorie, Practică, 2020
The article is dedicated to the analysis of cycles of lieds written by Cornel Țăranu and Dan Voiculescu, two remarkable representatives of the Romanian composition school, on the lyrics of Nichita Stănescu. The author focuses on the compositional aspects,
GAMURARI, PAVEL
doaj  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Poesia i música: intertextualitats / Poésie et musique : intertextualités Poesía y música: intertextualidades Poetry and music: intertextualities

open access: yesTemps d'Educació, 2012
Poesia i música, ja des dels seus orígens, han estat estretament relacionades. Aquest article n’explora els diferents nivells d’intertextualitat i la seva aplicació didàctica.
Júlia Ferrer i Garcia   +1 more
doaj  

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

open access: yesFEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

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