Results 81 to 90 of about 874,910 (336)

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Transmissão psíquica transgeracional e construção de subjetividade: relato de uma psicoterapia psicanalítica vincular1

Psicologia USP
O presente artigo tem como objetivo refletir acerca do conceito de transmissão psíquica entre gerações, especificamente de uma modalidade - a transmissão psíquica transgeracional - e sua influência na construção das subjetividades individuais e dos ...
Isabel Cristina Gomes, Sandra Aparecida S. Zanetti   +1 more
doaj  

Galois Identities of the three term recurrence [PDF]

, 2013
We study the existence of the identity L_n^2 -5F_n^2 = 4(-1 ...
Cheng Lien, Lang, Mong Lung Lang
core  

Intermolecular Electronic Coupling of Organic Units for Efficient Persistent Room‐Temperature Phosphorescence

Angewandte Chemie, 2016
Although persistent room‐temperature phosphorescence (RTP) emission has been observed for a few pure crystalline organic molecules, there is no consistent mechanism and no universal design strategy for organic persistent RTP (pRTP) materials.
Zhiyong Yang, Z. Mao, Xuepeng Zhang, D. Ou, Y. Mu, Yi Zhang, Cunyuan Zhao, Siwei Liu, Zhenguo Chi, Jia-rui Xu, Yuan-chun Wu, Po-yen Lu, A. Lien, M. Bryce   +13 more
semanticscholar   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

UIO-Lien: Entailment Recognition using Minimal Recursion Semantics

International Workshop on Semantic Evaluation, 2014
In this paper we present our participation in the Semeval 2014 task “Evaluation of compositional distributional semantic models on full sentences through semantic relatedness and textual entailment”.
Elisabeth Lien, Milen Kouylekov
semanticscholar   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Challenges to accessing community dementia care services: a qualitative study

BMC Health Services Research
Background Community dementia care services are designed to support persons with dementia (PWDs) and their caregivers. Despite their importance, these services are underutilized. Previous studies have typically focused on challenges in accessing specific
Chandrika Ramakrishnan, Chetna Malhotra
doaj   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Numerical simulations of cometary dust [PDF]

Most observations of comets are done photometrically or spectrophotometrically. The interpretation of the aperture-averaged flux is relatively simple for an isotropic, radially expanding coma of infinite extent - the canonical model.
Lien, David J.
core   +1 more source