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Beyond the Skin: Assessing Itch in Atopic Dermatitis – Insights from UK Dermatologists. A Cross-Sectional Survey and Narrative Review [PDF]

Dermatology and Therapy
Background Chronic itch is the most burdensome symptom of atopic dermatitis (AD), yet its routine assessment and measurement remain inconsistent.
Philip Laws, Alberto Barea, Georgina Fremlin, Charlene Murphy, Daniel Guirguis, Dominika Michno, Kave Shams   +6 more
doaj   +2 more sources

The molecular and cellular mechanisms of itch and the involvement of TRP channels in the peripheral sensory nervous system and skin

Allergology International, 2017
Itch is an unpleasant cutaneous sensation that can arise following insect bites, exposure to plant ingredients, and some diseases. Itch can also have idiopathic causes. Itch sensations are thought to protect against external insults and toxic substances.
Makoto Tominaga
exaly   +3 more sources

Phase-Space Modeling and Control of Robots in the Screw Theory Framework Using Geometric Algebra

Mathematics, 2023
The following paper talks about the dynamic modeling and control of robot manipulators using Hamilton’s equations in the screw theory framework. The difference between the proposed work with diverse methods in the literature is the ease of obtaining the ...
Jesús Alfonso Medrano-Hermosillo, Ricardo Lozoya-Ponce, Abraham Efraím Rodriguez-Mata, Rogelio Baray-Arana   +3 more
doaj   +1 more source

Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis

Acta Dermato-Venereologica, 2023
Crisaborole, a phosphodiesterase 4 (PDE4) inhibitor, has been approved for the treatment of mild to moderate atopic dermatitis. Atopic dermatitis is often associated with increased pain.
Darya Pavlenko, Zeynep Todurga Seven, Lauren Bystrom, Anika Markan, Rebecca Verpile, Hirotake Ishida, Tasuku Akiyama   +6 more
doaj   +1 more source

Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review

Dermatology and Therapy, 2023
Chronic spontaneous urticaria (CSU) is a condition in which wheals, angioedema, and pruritus occur spontaneously and recurrently for at least 6 weeks. The etiology of this disease is partially dependent on production of autoantibodies that activate and ...
Gil Yosipovitch, Georgia Biazus Soares, Omar Mahmoud   +2 more
doaj   +1 more source

Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors

Nature Communications, 2020
The role of gastrin related peptide (GRP+) neurons in itch is debated. Here, the authors generate a conditional knock-in mouse to label and manipulate GRP expressing DRG neurons and investigate their role in itch and nociception.
Devin M. Barry, Xue-Ting Liu, Benlong Liu, Xian-Yu Liu, Fang Gao, Xiansi Zeng, Juan Liu, Qianyi Yang, Steven Wilhelm, Jun Yin, Ailin Tao, Zhou-Feng Chen   +11 more
doaj   +1 more source

Predictive factors of quality of life in chronic pruritus patients: A cross-sectional studyCapsule Summary

JAAD International, 2023
Background: Chronic pruritus severely impacts the quality of life (QoL) of patients. Due to its multifactorial nature, the presence of factors that can predict itch-specific QoL needs comprehensive exploration.
Siri Choragudi, BS, Georgia Biazus Soares, BHS, Gil Yosipovitch, MD   +2 more
doaj   +1 more source

Role of burn severity and posttraumatic stress symptoms in the co-occurrence of itch and neuropathic pain after burns: A longitudinal study

Frontiers in Medicine, 2022
Itch and pain are common after burns. Neuropathic mechanisms may underlie both modalities but remain not well-understood. This study aims to prospectively document neuropathic pain symptoms and to identify potential itch symptom profiles that differ ...
N. E. E. Van Loey, N. E. E. Van Loey, A. E. E. de Jong, H. W. C. Hofland, A. I. M. van Laarhoven, A. I. M. van Laarhoven   +5 more
doaj   +1 more source

A spinal neural circuitry for converting touch to itch sensation

Nature Communications, 2020
Light touch can sometimes induce unpleasant itch sensation but the neural correlates of this conversion are not well studied. Here, the authors provide evidence that Tac2 expressing spinal interneurons are connected to gastrin-releasing peptide receptor (
Sihan Chen, Xiao-Fei Gao, Yuxi Zhou, Ben-Long Liu, Xian-Yu Liu, Yufen Zhang, Devin M. Barry, Kun Liu, Yingfu Jiao, Rita Bardoni, Weifeng Yu, Zhou-Feng Chen   +11 more
doaj   +1 more source

Mindfulness as Predictor of Itch Catastrophizing in Patients With Atopic Dermatitis: Results of a Cross-Sectional Questionnaire Study

Frontiers in Medicine, 2021
Itch and worry about itch are predominant symptoms in atopic dermatitis (AD). Mindfulness refers to paying attention in a certain way, non-judgementally and on purpose. In patients with chronic pain, which shares several similarities with chronic itch, a
Kjell Lüßmann, Kerry Montgomery, Andrew Thompson, Uwe Gieler, Christoph Zick, Joerg Kupfer, Christina Schut   +6 more
doaj   +1 more source