Results 1 to 10 of about 129,163 (299)
Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis [PDF]
eLife, 2019 Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the ...
Carolyn M Walsh +11 more
doaj +3 more sources
PLoS ONE, 2013 BackgroundEven though itch is a common syndrome of many diseases there is only little knowledge about sex and gender differences in pruritus, especially in central itch perception and modulation.
Astrid Stumpf +7 more
doaj +3 more sources
Molecular Cancer, 2018 Background Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin protein ligase (ITCH) and tumor suppressor served as a sponge for certain miRNAs targeting their parental transcripts of ITCH.
Xiao Yang, Jie Han, Haiwei Yang
exaly +3 more sources
Phase-Space Modeling and Control of Robots in the Screw Theory Framework Using Geometric Algebra
Mathematics, 2023 The following paper talks about the dynamic modeling and control of robot manipulators using Hamilton’s equations in the screw theory framework. The difference between the proposed work with diverse methods in the literature is the ease of obtaining the ...
Jesús Alfonso Medrano-Hermosillo +3 more
doaj +1 more source
Acta Dermato-Venereologica, 2023 Crisaborole, a phosphodiesterase 4 (PDE4) inhibitor, has been approved for the treatment of mild to moderate atopic dermatitis. Atopic dermatitis is often associated with increased pain.
Darya Pavlenko +6 more
doaj +1 more source
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis [PDF]
, 2018 Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer.
Alfonsi, Romina +22 more
core +17 more sources
Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review
Dermatology and Therapy, 2023 Chronic spontaneous urticaria (CSU) is a condition in which wheals, angioedema, and pruritus occur spontaneously and recurrently for at least 6 weeks. The etiology of this disease is partially dependent on production of autoantibodies that activate and ...
Gil Yosipovitch +2 more
doaj +1 more source
Nature Communications, 2020 The role of gastrin related peptide (GRP+) neurons in itch is debated. Here, the authors generate a conditional knock-in mouse to label and manipulate GRP expressing DRG neurons and investigate their role in itch and nociception.
Devin M. Barry +11 more
doaj +1 more source
JAAD International, 2023 Background: Chronic pruritus severely impacts the quality of life (QoL) of patients. Due to its multifactorial nature, the presence of factors that can predict itch-specific QoL needs comprehensive exploration.
Siri Choragudi, BS +2 more
doaj +1 more source
Silencing E3 Ubiqutin ligase ITCH as a potential therapy to enhance chemotherapy efficacy in p53 mutant neuroblastoma cells [PDF]
, 2020 P53 mutations are responsible for drug-resistance of tumour cells which impacts on the efficacy of treatment. Alternative tumour suppressor pathways need to be explored to treat p53- deficient tumours.
Hart, Stephen L +2 more
core +2 more sources