Results 41 to 50 of about 42,908 (304)

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

On Itch in an Algiatrist [PDF]

Pain Medicine, 2008
We physicians call it pruritus, and we prescribe pills, lotions, ointments, and creams. We patients call it itching, and we scratch and scratch and scratch. Chronic itch may have a low profile as a medical problem, but it can totally disrupt the life of a patient. At its mildest, chronic itch is just an irritation, but at its worst, chronic itch can be
openaire   +2 more sources

Suppression of scratching-induced pleasurable sensation by compression nerve blocking and its association with itch relief

, 2017
Supplemental Digital Content is available in the text. Itch can be suppressed by scratching. At the same time, scratching evokes a pleasurable sensation.
Gil Yosipovitch, Nattkemper, Leigh A, Leigh A. Nattkemper, Hideki Mochizuki, Alina Shevchenko, Mochizuki, Hideki, Shevchenko, Alina, Valdes-Rodriguez, Rodrigo, Rodrigo Valdes-Rodriguez, Yosipovitch, Gil   +9 more
core   +1 more source

Itch in Organs Beyond the Skin

, 2020
The purpose of this review was to explore mechanisms, causes, and therapies of itchy conditions involving organs beyond the skin including the eyes, ears, nose, and genital region.
Smith, Peter, Golpanian, Rachel Shireen, Yosipovitch, Gil   +2 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The prevalence and characteristics of chronic ocular itch: a cross-sectional survey

, 2017
In this cross-sectional study, we aimed to determine the prevalence and characteristics of chronic ocular itch in an outpatient ophthalmology and optometry clinic. Four hundred patients from an outpatient ophthalmology and optometry clinic were enrolled.
William J. Foster, Martin J. Schardt, Foster, William J, Sydney Tabaac, Leigh A. Nattkemper, Valdes-Rodriguez, Rodrigo, Shafer, Brian M, Dany M. Najjar, Schardt, Martin J, Stull, Carolyn, Gil Yosipovitch, Nattkemper, Leigh A, Tabaac, Sydney, Yiong-Huak Chan, Alina Shevchenko, Shevchenko, Alina, Chan, Yiong-Huak, Rodrigo Valdes-Rodriguez, Carolyn Stull, Brian M. Shafer, Najjar, Dany M, Yosipovitch, Gil   +21 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source