Results 61 to 70 of about 129,163 (299)

Cardiac-specific ITCH overexpression ameliorates septic cardiomyopathy via inhibition of the NF-κB signaling pathway

Journal of Molecular and Cellular Cardiology Plus, 2022
Background: Septic cardiomyopathy is a common complication of septic shock and organ dysfunction. ITCH is a HECT (homologous to the E6-AP carboxyl-terminus)-type ubiquitin E3 ligase that plays a critical role in inflammatory suppression.
Yuji Saito, Yoichiro Otaki, Tetsu Watanabe, Shingo Tachibana, Junya Sato, Yuta Kobayashi, Tomonori Aono, Jun Goto, Masahiro Wanezaki, Daisuke Kutsuzawa, Shigehiko Kato, Harutoshi Tamura, Satoshi Nishiyama, Takanori Arimoto, Hiroki Takahashi, Masafumi Watanabe   +15 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Novel Topical Treatments for Itch

Dermatology and Therapy
The experience of itch often poses a burden on patient quality of life and has the capacity to inflict significant suffering. Topical therapies are a mainstay of treatment for many cutaneous and systemic diseases and afford patients the opportunity to ...
Rami H. Mahmoud, Omar Mahmoud, Georgia Biazus Soares, Gil Yosipovitch   +3 more
doaj   +1 more source

Exploring content and psychometric validity of newly developed assessment tools for itch and skin pain in atopic dermatitis. [PDF]

, 2019
BackgroundAtopic dermatitis (AD) is a common skin disorder characterized by chronic inflammation, altered skin barrier function, and inflammatory cell skin infiltration that decreases health-related quality of life (HRQoL).
Abetz-Webb, Linda, DeLozier, Amy M, Eichenfield, Lawrence F, Gable, Jonathon C, Griffiths, Philip C, Hill, Jennifer N, Hudgens, Stacie, Newton, Louise, Paik, Jim, Silverberg, Jonathan I, Symonds, Tara, Wyrwich, Kathleen W   +11 more
core  

Chronic itch development in sensory neurons requires BRAF signaling pathways [PDF]

, 2013
Chronic itch, or pruritus, is associated with a wide range of skin abnormalities. The mechanisms responsible for chronic itch induction and persistence remain unclear.
Barry, Devin M., Battey, James F., Chen, Zhou-Feng, Cornelius, Lynn A., Demehri, Shadmehr, Hampton, Lori, Huo, Fu-Quan, Jeffry, Joseph, Kim, Seungil, Kopan, Raphael, Li, Hui, Liu, Xian-Yu, Liu, Zhong-Chun, Ma, Kaijie, Turkoz, Ahu, Wan, Li, Zhao, Zhong-Qiu, Zhong, Jian   +17 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Circular RNA ITCH Is a Tumor Suppressor in Clear Cell Renal Cell Carcinoma Metastasis through miR-106b-5p/PDCD4 Axis

Journal of Immunology Research, 2021
High metastasis of clear cell renal cell carcinoma (ccRCC) significantly influenced survival rate of ccRCC patients. Here, we intended to investigate the impacts of circular RNA ITCH (circ-ITCH) on the metastasis of ccRCC.
Ping Gao, Yong Huang, Yanmei Hou, Qian Li, Haimei Wang   +4 more
doaj   +1 more source

Aquarium dermatitis: Cercarial dermatitis in an aquarist [PDF]

, 1998
A 33-year-old man presented with very itchy red papules on the back of his hands and forearms. These papules appeared about 90 min after he had cleaned his aquarium in which he kept native fish and watersnails.
Bastert, J., Korting, Hans Christian, Sing, A., Wollenberg, A.   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

CircRNA Circ-ITCH Inhibits the Proliferation and Invasion of Glioma Cells Through Targeting the miR-106a-5p/SASH1 Axis

Cell Transplantation, 2021
Circ-ITCH, a novel circRNA, was generated from several exons of itchy E3 ubiquitin protein ligase (ITCH). Recently, circ-ITCH has been demonstrated to be involved in cancer development.
Wei Chen, Ming Wu, Si-Tong Cui, Yue Zheng, Zhen Liu, Liang-Sheng Luo   +5 more
doaj   +1 more source