Results 61 to 70 of about 39,357 (305)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Decreased Responsiveness to Chemical Itch in Old Mice

Cells
Aging is associated with altered itch perception, potentially due to changes in neuronal function and pruriceptive signaling. The underlying mechanisms, however, remain unclear.
Qiaofeng Zhao, Mitsutoshi Tominaga, Sumika Toyama, Kotaro Honda, Eriko Komiya, Yayoi Kamata, Hang Ma, Kenji Takamori   +7 more
doaj   +1 more source

Cardiac-specific ITCH overexpression ameliorates septic cardiomyopathy via inhibition of the NF-κB signaling pathway

Journal of Molecular and Cellular Cardiology Plus, 2022
Background: Septic cardiomyopathy is a common complication of septic shock and organ dysfunction. ITCH is a HECT (homologous to the E6-AP carboxyl-terminus)-type ubiquitin E3 ligase that plays a critical role in inflammatory suppression.
Yuji Saito, Yoichiro Otaki, Tetsu Watanabe, Shingo Tachibana, Junya Sato, Yuta Kobayashi, Tomonori Aono, Jun Goto, Masahiro Wanezaki, Daisuke Kutsuzawa, Shigehiko Kato, Harutoshi Tamura, Satoshi Nishiyama, Takanori Arimoto, Hiroki Takahashi, Masafumi Watanabe   +15 more
doaj   +1 more source

Paraneoplastic itch: an expert position statement from the Special Interest Group (SIG) of the International Forum on the Study of Itch (IFSI)

, 2015
In clinical practice, the term "paraneoplastic itch" is used to describe itch in patients with cancer. Patients with hematological or solid tumor malignancies can be affected. In general, paraneoplastic itch is considered a rare disorder.
Weisshaar, Elke, Mettang, Thomas, Zylicz, Zbigniew, Special Interest Group of the International Forum on the Study of Itch, Weiss, Melanie, Yosipovitch, Gil   +5 more
core   +1 more source

Neuropathic Itch [PDF]

, 2018
Chronic itch can be caused by dysfunctions of itch-sensing neurons that produce sensory hallucinations of pruritogenic stimuli. The cellular and molecular mechanisms are still unknown.
Oaklander, Anne
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch.

PLoS ONE, 2011
BackgroundHistamine is the prototypical pruritogen used in experimental itch induction. However, in most chronic pruritic diseases, itch is not predominantly mediated by histamine.
Alexandru D P Papoiu, Hong Liang Tey, Robert C Coghill, Hui Wang, Gil Yosipovitch   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Evoked itch perception is associated with changes in functional brain connectivity

NeuroImage: Clinical, 2015
Chronic itch, a highly debilitating condition, has received relatively little attention in the neuroimaging literature. Recent studies suggest that brain regions supporting itch in chronic itch patients encompass sensorimotor and salience networks, and ...
Gaëlle Desbordes, Ang Li, Marco L. Loggia, Jieun Kim, Peter C. Schalock, Ethan Lerner, Thanh N. Tran, Johannes Ring, Bruce R. Rosen, Ted J. Kaptchuk, Florian Pfab, Vitaly Napadow   +11 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source