Results 61 to 70 of about 42,908 (304)

Decreased Responsiveness to Chemical Itch in Old Mice

Cells
Aging is associated with altered itch perception, potentially due to changes in neuronal function and pruriceptive signaling. The underlying mechanisms, however, remain unclear.
Qiaofeng Zhao, Mitsutoshi Tominaga, Sumika Toyama, Kotaro Honda, Eriko Komiya, Yayoi Kamata, Hang Ma, Kenji Takamori   +7 more
doaj   +1 more source

TRPV1 activity and substance P release are required for corneal cold nociception

Nature Communications, 2019
The eye shows protective responses to noxious stimuli including cold. Here, the authors show that TRPV1, found co-expressed on TRPM8 + fibres in the cornea, is necessary for cold nociception in the eye.
Fengxian Li, Weishan Yang, Haowu Jiang, Changxiong Guo, Andrew J. W. Huang, Hongzhen Hu, Qin Liu   +6 more
doaj   +1 more source

Neuroimmune Mediators of Pruritus in Hispanic Scalp Psoriatic Itch

Acta Dermato-Venereologica, 2023
Scalp psoriatic itch is a common, bothersome, yet understudied, condition with numerous associated treatment challenges. The aim of this study was to enhance our understanding of the pathophysiology of scalp psoriatic itch.
Leigh A. Nattkemper, Zoe M. Lipman, Giuseppe Ingrasci, Claudia Maldonado, Juan Carlos Garces, Enrique Loayza, Gil Yosipovitch   +6 more
doaj   +1 more source

Attentional processing of itch [PDF]

, 2017
Itch is a prevalent somatosensory symptom that can be highly disabling, because it is likely to draw attention and, as a result, may interfere with the performance of daily activities.
Evers, AWM, D. M. van Ryckeghem, Ryckeghem, D.M. van, Crombez, G., Van Damme, Stefaan, van Damme, S., A. I. M. van Laarhoven, Laarhoven, A.I.M. van, A. P. M. Lavrijsen, A. W. M. Evers, Damme, S. Van, van Laarhoven, AIM, Crombez, Geert, Lavrijsen, A. P. M., S. van Damme, van Laarhoven, A. I. M., Van Ryckeghem, Dimitri, Evers, A.W.M., G. Crombez, Lavrijsen, APM, van Ryckeghem, D. M.; id_orcid, Evers, A. W. M., van Ryckeghem, D. M., Lavrijsen, A.P.M.   +23 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Sex differences in itch perception and modulation by distraction--an FMRI pilot study in healthy volunteers.

PLoS ONE, 2013
BackgroundEven though itch is a common syndrome of many diseases there is only little knowledge about sex and gender differences in pruritus, especially in central itch perception and modulation.
Astrid Stumpf, Markus Burgmer, Gudrun Schneider, Gereon Heuft, Martin Schmelz, Ngoc Quan Phan, Sonja Ständer, Bettina Pfleiderer   +7 more
doaj   +1 more source

Pathophysiology of Itch [PDF]

Dermatologic Clinics, 2018
Chronic itch is a clinically challenging yet scientifically remarkable and complex process. Increasing understanding of the pathophysiology of chronic itch is leading to targeted therapeutic approaches that are now dramatically improving quality of life. This improvement will accelerate as the tools of basic and clinical research continue to be applied
openaire   +2 more sources

Paraneoplastic itch: an expert position statement from the Special Interest Group (SIG) of the International Forum on the Study of Itch (IFSI)

, 2015
In clinical practice, the term "paraneoplastic itch" is used to describe itch in patients with cancer. Patients with hematological or solid tumor malignancies can be affected. In general, paraneoplastic itch is considered a rare disorder.
Weisshaar, Elke, Mettang, Thomas, Zylicz, Zbigniew, Special Interest Group of the International Forum on the Study of Itch, Weiss, Melanie, Yosipovitch, Gil   +5 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source