Results 71 to 80 of about 42,908 (304)

A subpopulation of projections from the parabrachial nucleus to the central amygdala mediates itch

Scientific Reports
The parabrachial nucleus (PBN) plays a crucial role in transmitting itch and affective pain signals to the brain regions such as the central amygdala (CeA).
Darya Pavlenko, Hirotake Ishida, Anika Markan, Tasuku Akiyama   +3 more
doaj   +1 more source

Evoked itch perception is associated with changes in functional brain connectivity

NeuroImage: Clinical, 2015
Chronic itch, a highly debilitating condition, has received relatively little attention in the neuroimaging literature. Recent studies suggest that brain regions supporting itch in chronic itch patients encompass sensorimotor and salience networks, and ...
Gaëlle Desbordes, Ang Li, Marco L. Loggia, Jieun Kim, Peter C. Schalock, Ethan Lerner, Thanh N. Tran, Johannes Ring, Bruce R. Rosen, Ted J. Kaptchuk, Florian Pfab, Vitaly Napadow   +11 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

The Challenge of Basic Itch Research

Acta Dermato-Venereologica, 2020
Basic mechanisms and pathways of itch signaling are reviewed, with an emphasis on the progress to date as well as remaining challenges in translating current knowledge to the clinical treatment of chronic itch.
Earl Carstens, Taylor Follansbee, Mirela Iodi Carstens   +2 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

The Functional Network Processing Acute Electrical Itch Stimuli in Humans

Frontiers in Physiology, 2019
The posterior insula (pIns) is a major brain region that receives itch-related signals from the periphery and transfers these signals to broad areas in the brain.
Hideki Mochizuki, Hideki Mochizuki, Loren E. Hernandez, Gil Yosipovitch, Norihiro Sadato, Ryusuke Kakigi   +5 more
doaj   +1 more source

Modulation of itch by conditioning itch and pain stimulation in healthy humans [PDF]

, 2017
Little is known about endogenous descending control of itch. In chronic pain, descending pain inhibition is reduced as signified by lowered conditioned pain modulation (CPM).
Arendt-Nielsen, Lars, Antoinette I.M. van Laarhoven, Andersen, Hjalte Holm, Laarhoven, A.I.M. van, Elberling, Jesper, van Laarhoven, Antoinette I.M., Jesper Elberling, Elberling, J., Andersen, Hjalte H., Lars Arendt-Nielsen, Andersen, H.H., Arendt-Nielsen, L., van Laarhoven, Antoinette I. M., Hjalte H. Andersen   +13 more
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Advances in understanding itching and scratching: a new era of targeted treatments [version 1; referees: 2 approved]

F1000Research, 2016
Chronic itch is a significant health burden with few effective treatments. As such, itch researchers seek to understand the mechanisms behind itch and to find potential targets for treatment.
Kristen M. Sanders, Leigh A. Nattkemper, Gil Yosipovitch   +2 more
doaj   +1 more source