Results 61 to 70 of about 317,358 (309)

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Bibliothèques, outils du lien social en milieu périurbain (Les) [PDF]

Les zones périurbaines accueillent des populations variées, dont les besoins et usages diffèrent fortement. Ces espaces protéiformes ont vocation à soutenir le lien social, afin d\u27 impulser une nouvelle dynamique à des territoires situés entre l ...
CUSSAC, Mathilde
core  

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

Lien social et communauté locale: quelques questions préalables

Lien Social et Politiques, 1998
La fin du providentialisme et la montée de l'individualisme néolibéral figurent parmi les principaux éléments du diagnostic de notre mal de vivre social actuel.
Johanne Charbonneau
doaj   +1 more source

Qu'avons nous en commun? [PDF]

, 2010
ce texte est l'introduction générale de l'ouvrage collectif du groupe "communication et solidarité"To think of the social link in our democracies asks for two things: a multidimentional and empirical research.
Dacheux, Eric
core   +2 more sources

MPI‐Guided Photothermal Therapy of Prostate Cancer Using Stem Cell Delivery of Magnetotheranostic Nanoflowers

Advanced Functional Materials, EarlyView.
Tumor‐tropic human mesenchymal stem cells (hMSCs) were used as delivery vehicles for magnetotheranostic gold–iron oxide nanoflowers. Magnetic particle imaging of the iron component demonstrated widespread intratumoral distribution and sustained retention in contrast to injection of naked nanoflowers.
Behnaz Ghaemi, Ana Rosu, Shreyas Kuddannaya, Gautier Laurent, Rana Bazzi, Stéphane Roux, Ali Shakeri‐Zadeh, Jeff W. M. Bulte   +7 more
wiley   +1 more source

L'ÊTHIQUE DU LIEN SOCIAL

Reflexão
Les sociétés contemporaines - celtes du Nord en particulier - sont frappées par un courant d’individualisme qui n’a d’égal que des formes de plus en plus grandes d’exclusion dont sont l’objet des couches importantes de leurs populations, victimes de ...
Guy GIROUX
doaj  

L'adolescent, la différence et le lien social

Revista Latinoamericana de Psicopatologia Fundamental
L’auteur montre que si l’adolescent questionne autant la famille et la civilisation moderne dans leur rapport aux idéaux, c’est parce qu’à travers lui se repose avec acuité la question de la différence, interpellant l’autre au cœur de ce qui le fonde et ...
Rajaa Stitou
doaj   +1 more source

The Implicit Takings Jurisprudence of Article 9 of the Uniform Commercial Code [PDF]

, 1995
Part I of this Article begins by reasserting that central to the idea of property rights is the legal entitlement to remedies that permits a person to exercise dominion over the specific asset or to exclude the exercise of dominion by others.
Frisch, David
core   +2 more sources