Results 41 to 50 of about 11,856,235 (233)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Communication politique et passion

Altre Modernità, 2010
The interaction between communication, politics and passion holds reality together, the analysis of which leads to a better knowledge of the foundation of the civil bond.
Jole Morgante
doaj   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

L’apprentissage de la citoyenneté sociale : une dimension négligée à l’école ? Une comparaison France/Québec

L’Éducation en Débats
L’éducation à la citoyenneté est devenue un enjeu incontournable des systèmes éducatifs français et québécois. Cependant, la dimension sociale de la citoyenneté semble être négligée et source de malentendus pour les acteurs/trices de l’éducation.
Marie-Laure Harmand
doaj   +1 more source

LE COUPLE : UNE TENTATIVE DE CRÉER LA SOCIALITÉ [PDF]

Studii si Cercetari Filologice: Seria Limbi Romanice, 2009
Notre étude interdisciplinaire se propose d’intégrer la notion de « socialité », exploitée surtout par le sociologue français Michel Maffesoli, à l’analyse littéraire du roman « Les Grandes Marées » de l’écrivain québécois Jacques Poulin.
Liliana VOICULESCU
doaj  

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

L’effervescence publique entretient-elle le lien social ?

EspacesTemps.net, 2007
Il faut commencer par un rappel, auquel l’auteur, chargé de recherches au Cnrs (Amiens), ne cesse de nous reconduire : il existe de nombreux présupposés, répétés à satiété, concernant les rituels politiques et les comportements collectifs dans les lieux ...
Vladimir Bertrand, Christian Ruby
doaj  

Alliance et lien social en Languedoc (XVIIe-XVIIIe s.)

Estudis d'Història Agraria, 2011
El model familiar que predominava al Baix Llanguedoc en el segle xviii presenta moltes similituds amb aquells que existien als Pirineus, al Massís Central o a l’Alta Provença: es basava en la devolució de la majoria dels béns a un únic hereu universal ...
Elie Pélaquier
doaj   +1 more source