Results 31 to 40 of about 11,856,235 (233)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

La presse quotidienne régionale revisitée par la géolocalisation

open access: yesInterfaces Numériques, 2018
La géolocalisation constituerait un défi du point de vue de la presse quotidienne régionale dans un contexte où les applications y recourant se multiplient.
Bénédicte Toullec
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

La nouvelle figure du travailleur précaire assisté

open access: yesLien Social et Politiques, 2009
Avec l’instauration du Revenu de solidarité active (RSA) en juin 2009, la France connaît une réforme d’envergure de sa politique de lutte contre la pauvreté.
Serge Paugam, Claude Martin
doaj   +1 more source

La pratique psychanalytique et sa jouis-science

open access: yesRevista Latinoamericana de Psicopatologia Fundamental, 2014
Peut-on soutenir l'existence d'une vraie différence entre la science au sens moderne - sens qui se pose comme absolu - et le discours scientifique, dans le dernier enseignement de Lacan?
Tania Coelho dos Santos
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

open access: yesFEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

open access: yesAging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho   +4 more
wiley   +1 more source

Symptôme… σύμπτωμα... sumptoma

open access: yesDesde el Jardín de Freud, 2012
El artículo propone un estudio del síntoma y de sus dimensiones etimológica, teórica y clínica. La primera dimensión aborda su etimología griega y latina; la segunda trata el síntoma en la enseñanza freudiana, desde el descubrimiento del inconsciente y ...
Frédérique Berger
doaj  

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