Results 1 to 10 of about 96,771 (207)

A humanized LIF-targeting antibody synergistically enhances chemo- and immunotherapy in pancreatic cancer [PDF]

Journal of Translational Medicine
Background Pancreatic cancer is associated with a low survival rate due to its late diagnosis, and the patients’ resistance to chemotherapy and immunotherapy.
Fu Xu, Wei Liu, Luying Su, Lang Yang, Yiyao Zhang, Baoqing Liu, Shuaihu Liu, Zuoming Liu, Ziran Chen, Yan Lu, Ning Zhang, Rong Huang, Hong Zhao, Wei Song   +13 more
doaj   +2 more sources

Tumor-Derived LIF Promotes GDF15-Driven Cachexia and Adverse Outcomes in Gastric Cancer [PDF]

Cells
Cancer cachexia is a multifactorial metabolic syndrome characterized by progressive skeletal muscle and adipose tissue loss, systemic inflammation, and poor clinical outcomes, and represents a major unmet clinical need in gastric cancer.
Cristina Di Giorgio, Nicola Natalizi, Maria Rosaria Sette, Martina Bordoni, Benedetta Sensini, Ginevra Lachi, Eleonora Giannelli, Francesca Paniconi, Luigi Cari, Silvia Marchianò, Michele Biagioli, Elva Morretta, Maria Chiara Monti, Bruno Charlier, Fabrizio Dal Piaz, Angela Zampella, Eleonora Distrutti, Luigina Graziosi, Annibale Donini, Stefano Fiorucci   +19 more
doaj   +2 more sources

Evolving spiking neural networks: the role of neuron models and encoding schemes in neuromorphic learning [PDF]

Frontiers in Neuroscience
This study investigates the impact of neuron models and encoding schemes on the performance of spiking neural networks trained using the NeuroEvolution of Augmenting Topologies (NEAT) algorithm.
Bastian Loyola-Jara, Gabriela Fernández-Rodríguez, Javier Baladron   +2 more
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Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosisResearch in context

EBioMedicine, 2022
Summary: Background: The role of the IL6 family members in organ fibrosis, including renal interstitial fibrosis (TIF), has been widely explored. However, few studies have ever simultaneously examined them in the same cohort of patients.
Shihui Xu, Xiaobing Yang, Qingzhou Chen, Zhuoliang Liu, Ying Chen, Xiaotian Yao, An Xiao, Jianwei Tian, Liling Xie, Miaomiao Zhou, Zheng Hu, Fengxin Zhu, Xin Xu, Fanfan Hou, Jing Nie   +14 more
doaj   +1 more source

Targeting LIF/LIFR signaling in cancer

Genes and Diseases, 2022
Leukemia inhibitory factor (LIF), and its receptor (LIFR), are commonly over-expressed in many solid cancers and recent studies have implicated LIF/LIFR axis as a promising clinical target for cancer therapy.
Suryavathi Viswanadhapalli, Kalarickal V. Dileep, Kam Y.J. Zhang, Hareesh B. Nair, Ratna K. Vadlamudi   +4 more
doaj   +1 more source

LIF receptor‐gp130 interaction investigated by homology modeling: Implications for LIF binding [PDF]

Protein Science, 1998
AbstractLeukemia inhibitory factor (LIF), a member of the gpl30 family of helical cytokines, is involved in the hemopoietic and neural systems. The LIF signal transducing complex contains two receptor molecules, the LIF receptor (LIFR) and gp130. The extracellular region of the LIFR is unique in that it includes three membrane‐proximal fibronectin type
Smith, D.K., Treutlein, H.R.
openaire   +2 more sources

Recent Advances in Imaging of Light Propagation with Light-in-Flight Recording by Holography

Ultrafast Science, 2023
In the last few decades, there have been several advances in ultrafast imaging of light propagation with light-in-flight recording by holography (LIF holography), which can capture light propagation as a motion picture with a single shot in principle ...
Tomoyoshi Inoue, Takashi Kakue, Kenzo Nishio, Toshihiro Kubota, Osamu Matoba, Yasuhiro Awatsuji   +5 more
doaj   +1 more source

Thermodynamic modeling of the LiF–YF3 phase diagram [PDF]

Journal of Crystal Growth, 2012
4 pages, 3 ...
Santos, I. A. dos, Klimm, D., Baldochi, S. L., Ranieri, I. M.   +3 more
openaire   +2 more sources

An Integrative Approach to the Current Treatment of HIV-Associated Neurocognitive Disorders and the Implementation of Leukemia Inhibitor Factor as a Mediator of Neurocognitive Preservation

Life, 2023
HIV-associated neurocognitive disorders (HANDs) continue to impact patients despite antiretroviral therapy. A combination of antiretroviral therapies can diminish the HIV viral load to near undetectable levels, but fails to preserve neurocognitive ...
Andrés De Freitas-Suarez, Natalia Espinosa-Ponce, Natalia Alvarez-Roger, Arianna Iris Cabrera-Suarez, Guillermo Jiménez-Jordán, Rocio Vega-Roman, Mikhail Inyushin, Janaina M. Alves   +7 more
doaj   +1 more source

Modeling LiF and FLiBe Molten Salts with Robust Neural Network Interatomic Potentials [PDF]

ACS Applied Materials & Interfaces, 2021
Lithium-based molten salts have attracted significant attention due to their applications in energy storage, advanced fission reactors and fusion devices. Lithium fluorides and particularly 66.6%LiF-33.3¾F 2 (Flibe) are of considerable interest in nuclear systems, as they show an excellent ...
Stephen T. Lam, Qing-Jie Li, Ronald Ballinger, Charles Forsberg, Ju Li   +4 more
openaire   +6 more sources