Tumor-derived interleukin-1α and leukemia inhibitory factor promote extramedullary hematopoiesis. [PDF]
PLoS Biology, 2023 Extramedullary hematopoiesis (EMH) expands hematopoietic capacity outside of the bone marrow in response to inflammatory conditions, including infections and cancer.
Derek A G Barisas +9 more
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New insights into Chlamydia pathogenesis: Role of leukemia inhibitory factor [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Chlamydia trachomatis (Ct) is the leading cause of bacterial sexually transmitted infections worldwide. Since the symptoms of Ct infection are often subtle or absent, most people are unaware of their infection until they are tested or develop severe ...
Jun Wang +5 more
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Leukemia Inhibitory Factor: An Important Cytokine in Pathologies and Cancer [PDF]
Biomolecules, 2022 Leukemia Inhibitory Factor (LIF) is a member of the IL-6 cytokine family and is expressed in almost every tissue type within the body. Although LIF was named for its ability to induce differentiation of myeloid leukemia cells, studies of LIF in ...
Megan M. Jorgensen, Pilar de la Puente
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The dysregulation of leukemia inhibitory factor and its implications for endometriosis pathophysiology [PDF]
Frontiers in Immunology, 2023 Endometriosis is an estrogen dominant, chronic inflammatory disease characterized by the growth of endometrial-like tissue outside of the uterus. The most common symptoms experienced by patients include manifestations of chronic pelvic pain- such as pain
Katherine B. Zutautas +9 more
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Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis [PDF]
Cell Death and Disease, 2022 LIF, a multifunctional cytokine, is frequently overexpressed in many types of solid tumors, including breast cancer, and plays an important role in promoting tumorigenesis. Currently, how LIF promotes tumorigenesis is not well-understood.
Xuetian Yue +12 more
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Emerging Perspectives on Leukemia Inhibitory Factor and its Receptor in Cancer [PDF]
Frontiers in Oncology, 2021 Tumorigenesis and metastasis have deep connections to inflammation and inflammatory cytokines, but the mechanisms underlying these relationships are poorly understood.
Joe Christianson +5 more
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Low pH induces amiloride-sensitive expression of leukemia inhibitory factor in endometrial cells [PDF]
The Journal of Reproduction and DevelopmentAn association has been reported between a lower pH in the uterus and an increased rate of implantation. How low pH regulates endometrial function is unclear.
Miku OTSUGU +6 more
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Paeoniflorin Enhances Endometrial Receptivity through Leukemia Inhibitory Factor
Biomolecules, 2021 Despite advances in assisted reproductive technology, treatment for deficient endometrial receptivity is a major clinical unmet need. In our previous study, the water extract of Paeonia lactiflora Pall.
Hye-Rin Park +8 more
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Leukemia inhibitory factor and its receptor: expression and regulation in the porcine endometrium throughout the estrous cycle and pregnancy [PDF]
Asian-Australasian Journal of Animal Sciences, 2019 Objective Leukemia inhibitory factor (LIF) binds to a heterodimeric receptor composed of LIF receptor (LIFR) and glycoprotein 130 (GP130) to transmit signals into the cell.
Inkyu Yoo +5 more
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Effect of Different Concentrations of Leukemia Inhibitory Factor on Gene Expression of Vascular Endothelial Growth Factor-A in Trophoblast Tumor Cell Line [PDF]
International Journal of Fertility and Sterility, 2020 Background Several studies have shown that leukemia inhibitory factor (LIF) is one of the most important cytokines participating in the process of embryo implantation and pregnancy, while, the role of this factor on vascular endothelial factor-A (VEGF ...
Khodakaram Jahanbin +2 more
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