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Leukemia inhibitory factor (LIF) [PDF]

Cytokine and Growth Factor Reviews, 2015
Leukemia inhibitory factor (LIF) is the most pleiotropic member of the interleukin-6 family of cytokines. It utilises a receptor that consists of the LIF receptor β and gp130 and this receptor complex is also used by ciliary neurotrophic growth factor (CNTF), oncostatin M, cardiotrophin1 (CT1) and cardiotrophin-like cytokine (CLC).
Jeffrey J Babon, Nicos A. Nicola
exaly   +5 more sources

Establishment of leukemia inhibitory factor (LIF)-independent iPS cells with potentiated Oct4 [PDF]

Stem Cell Research, 2015
Leukemia inhibitory factor (LIF) is widely used to establish and maintain naïve pluripotent stem cells, including mouse embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Hiroyuki Hirai, Meri Firpo, Nobuaki Kikyo   +2 more
doaj   +4 more sources

Leukemia Inhibitory Factor: An Important Cytokine in Pathologies and Cancer

Biomolecules, 2022
Leukemia Inhibitory Factor (LIF) is a member of the IL-6 cytokine family and is expressed in almost every tissue type within the body. Although LIF was named for its ability to induce differentiation of myeloid leukemia cells, studies of LIF in ...
Megan M. Jorgensen, Pilar de la Puente
doaj   +3 more sources

The Role of Leukemia Inhibitory Factor in Attenuating Skeletal Muscle Atrophy: Mechanisms to Exercise Interventions [PDF]

Cells
Leukemia inhibitory factor (LIF), a member of the interleukin-6 (IL-6) cytokine family, is a well-characterized myokine with pleiotropic regulatory effects on skeletal muscle.
Na Jiang, Shiyi Wang, Jiaqiao Zhang, Dandan Jia   +3 more
doaj   +2 more sources

In Vivo Gene Transfer of Leukemia Inhibitory Factor (LIF) into Mouse Endometrium [PDF]

Journal of Assisted Reproduction and Genetics, 2002
Leukemia inhibitory factor (LIF) is important for embryogenesis and implantation. We aimed to transfect LIF gene into the mouse endometrium.Expression plasmids carried LIF and luciferase genes for transfer. After superovulation, 100 ICR mice were mated with vasectomized mice.
Horng-Der Tsai, Yao-Yuan Hsieh, Chi-Chen Chang   +2 more
exaly   +3 more sources

LIF/LIFR Signaling in Gastric Cancer: A Double‐Edged Sword in Tumor Progression and Therapeutic Resistance [PDF]

Cancer Medicine
Gastric cancer (GC) remains a major cause of cancer‐related mortality worldwide, driven by late‐stage diagnoses and poor survival outcomes. Leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (LIFR) are increasingly recognized as ...
Daniel Park, Kyung‐Il Kim, Yate‐Ching Yuan, Pranati Shah, Hannah Zhong, Yu‐Han Chen, Sharity Ondrejik, Ellen Choi, Sofia Guzman, Vitor Goes, Christiana Crook, Wenqi Wang, Dani Ran Castillo, Daneng Li   +13 more
doaj   +2 more sources

No association of leukemia inhibitory factor (LIF) DNA polymorphisms with multiple sclerosis [PDF]

Journal of Neuroimmunology, 2006
Neuropoietins such as leukemia inhibitory factor (LIF) have been shown to ameliorate experimental autoimmune encephalomyelitis (EAE) and promote oligodendrocyte survival in vivo. We tested whether two previously described LIF polymorphisms are associated with MS by genotyping these single nucleotide polymorphisms (SNPs) in a group of MS patients (n=110)
Veerle Somers, Niels Hellings, Tomasz Burzykowski   +2 more
exaly   +4 more sources

Maternal Leukemia Inhibitory Factor (LIF) Promotes Fetal Neurogenesis via a LIF-ACTH-LIF Signaling Relay Pathway [PDF]

Endocrinology, 2010
Leukemia inhibitory factor (LIF) promotes the proliferation of neuronal progenitor cells in the cerebrum. However, it remains unclear how fetal LIF level is regulated. Here we show evidence that maternal LIF signals drive fetal LIF levels via the placenta, thereby promoting neurogenesis in the fetal brain in rats.
Toshihisa Hatta, Hiroki Otani, Hiroki Shimada   +2 more
exaly   +3 more sources

The Role of Leukemia Inhibitory Factor in Counteracting the Immunopathology of Acute and Chronic Lung Inflammatory Diseases

Journal of Respiration, 2023
Leukemia inhibitory factor (LIF), a member of the IL-6 cytokine family, is highly expressed throughout the body in multiple tissues and cell types. LIF is primarily known to induce the differentiation of myeloid leukemia cells, but recent studies show ...
Howard Yu, Sahil Zaveri, Meshach Pillai, Harsha Taluru, Michael Schaible, Sahil Chaddha, Asad Ahmed, Said Tfaili, Patrick Geraghty   +8 more
doaj   +1 more source

An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy

Communications Biology, 2021
Hunter et al. engineer a high affinity, soluble variant of leukemia inhibitory factor receptor (LIFR) to serve as a ligand trap for the LIF cytokine. They further demonstrate that this engineered LIFR exhibits improved affinity relative to the wild-type ...
Sean A. Hunter, Brianna J. McIntosh, Yu Shi, R. Andres Parra Sperberg, Chie Funatogawa, Louai Labanieh, Erin Soon, Hannah C. Wastyk, Nishant Mehta, Catherine Carter, Tony Hunter, Jennifer R. Cochran   +11 more
doaj   +1 more source