Results 11 to 20 of about 4,728,853 (203)

Impact of LIF (leukemia inhibitory factor) expression in malignant melanoma

Experimental and Molecular Pathology, 2013
Leukemia inhibitory factor (LIF) signaling regulates cellular processes to maintain the self-renewal and pluripotency of embryonic stem (ES) cells. Independent of these capabilities, LIF was also identified to be responsible for cancer development and progression. However, its detailed cellular function in cancer remains unclear thus far.
Silke, Kuphal, Susanne, Wallner, Anja K, Bosserhoff   +2 more
openaire   +3 more sources

Leukemia inhibitory factor and its role in physiologic and pathological processes [PDF]

MedUNAB, 2006
Leukemia inhibitory factor (LIF) is celular comunication mediator that shows a very wide range of biologic activities that include the cell differentiation, cell growth and proliferation, cell trophic and anti-apoptotic effect, cell protection of ...
Grégory Alfonso García, Ómar Mejía, Ananías García Cardona, Dianney Clavijo Grimaldi, Jimmy Muñoz, Sergio Hernández   +5 more
doaj   +2 more sources

Upregulation of leukemia inhibitory factor (LIF) during the early stage of optic nerve regeneration in zebrafish. [PDF]

PLoS One, 2014
Fish retinal ganglion cells (RGCs) can regenerate their axons after optic nerve injury, whereas mammalian RGCs normally fail to do so. Interleukin 6 (IL-6)-type cytokines are involved in cell differentiation, proliferation, survival, and axon regrowth ...
Ogai K, Kuwana A, Hisano S, Nagashima M, Koriyama Y, Sugitani K, Mawatari K, Nakashima H, Kato S.   +8 more
europepmc   +5 more sources

Allogeneic Embryos Disregulate Leukemia Inhibitory Factor (LIF) and Its Receptor in the Porcine Endometrium During Implantation. [PDF]

Front Vet Sci, 2020
Despite its advantages for pig breeding, embryo transfer (ET) has a major handicap: high embryo mortality during the pre- and implantation period, probably caused by divergent phenomena of tolerance between the immunologically unrelated (i.e., allogeneic)
Cambra JM, Jauregi-Miguel A, Alvarez-Rodriguez M, Parrilla I, Gil MA, Martinez EA, Cuello C, Rodriguez-Martinez H, Martinez CA.   +8 more
europepmc   +2 more sources

Genetically Predicted Gut Microbial Taxa and Inflammatory Proteins Associated With Atrial Fibrillation: A Bidirectional Mendelian Randomization and Colocalization Study. [PDF]

J Arrhythm
A screen prioritized six microbial or inflammatory traits associated with AF by conventional MR and selectively evaluated them in a second AF GWAS. Sensitivity and cis/trans analyses indicated unequal robustness; the two‐instrument FGF‐5 cis‐only estimate remained preliminary; these findings are hypothesis‐generating, not established causal pathways or
Yi C, Zheng W, Zhao J, Cai W, Wang J, Song L, Bai M, Zhang Z.   +7 more
europepmc   +2 more sources

LIF-free embryonic stem cell culture in simulated microgravity. [PDF]

PLoS ONE, 2009
BackgroundLeukemia inhibitory factor (LIF) is an indispensable factor for maintaining mouse embryonic stem (ES) cell pluripotency. A feeder layer and serum are also needed to maintain an undifferentiated state, however, such animal derived materials need
Yumi Kawahara, Tomotaka Manabe, Masaya Matsumoto, Teruyuki Kajiume, Masayasu Matsumoto, Louis Yuge   +5 more
doaj   +1 more source

The effect of the anti-leukemia inhibitory factor on the immune system in the Balb/c mice bearing breast cancer induced with 4T1 cells

European Journal of Medical Research, 2023
Background Breast cancer is one of the most common cancers. Leukemia inhibitory factor (LIF) is considered as one of the effective factors in the growth of breast cancer, and anti-leukemia inhibitory factor antibody is considered as one of the treatment ...
Abolfazl Yavari, Fateme Zare, Hossein Hadinedoushan, Mohammad Taher Tahoori   +3 more
doaj   +1 more source

Targeting LIF/LIFR signaling in cancer

Genes and Diseases, 2022
Leukemia inhibitory factor (LIF), and its receptor (LIFR), are commonly over-expressed in many solid cancers and recent studies have implicated LIF/LIFR axis as a promising clinical target for cancer therapy.
Suryavathi Viswanadhapalli, Kalarickal V. Dileep, Kam Y.J. Zhang, Hareesh B. Nair, Ratna K. Vadlamudi   +4 more
doaj   +1 more source

Genome-wide identification and analysis of mRNA expression in fibroblasts, ES cells, and iPS cells

Genomics Data, 2016
Genome-wide expression patterns of mRNA were compared between mouse embryonic fibroblasts (MEFs), embryonic stem cells (ESCs), and various types of induced pluripotent stem cells (iPSCs).
Hiroyuki Hirai, Nobuaki Kikyo
doaj   +1 more source

Evaluation of vascular endothelial growth factor A and leukemia inhibitory factor expressions at the time of implantation in diabetic rats following treatment with Metformin and Pioglitazone

International Journal of Reproductive BioMedicine, 2020
Background: Implantation requires intimate crosstalk between the embryo and uterus for a successful establishment of pregnancy. Type 2 diabetes mellitus may lead to implantation failure. The effect of diabetes and its therapeutic drugs on implantation is
Ronak Zarei, Roshanak Aboutorabi, Bahman Rashidi, Nahid Eskandari, Parvaneh Nikpour   +4 more
doaj   +1 more source