Foxm1 mediates LIF/Stat3-dependent self-renewal in mouse embryonic stem cells and is essential for the generation of induced pluripotent stem cells. [PDF]
PLoS ONE, 2014 Activation of signal transducer and activator of transcription 3 (Stat3) by leukemia inhibitory factor (LIF) is required for maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs).
Guixiang Tan +4 more
doaj +1 more source
Life, 2023 HIV-associated neurocognitive disorders (HANDs) continue to impact patients despite antiretroviral therapy. A combination of antiretroviral therapies can diminish the HIV viral load to near undetectable levels, but fails to preserve neurocognitive ...
Andrés De Freitas-Suarez +7 more
doaj +1 more source
Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF [PDF]
, 2002 Injury to peripheral nerves results in the infiltration of immune cells, which remove axonal- and myelin-derived material. Schwann cells could play a key role in this process by regulating macrophage infiltration.
George K. Tofaris +7 more
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, 2022 Testicular Leydig cells (LCs) are the principal source of circulating testosterone in males. LC steroidogenesis maintains sexual function, fertility and general health, and is influenced by various paracrine factors.
Curley, M +9 more
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Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators? [PDF]
, 2004 Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM.
Kopp, F. B. +10 more
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Derivation of LIF-independent mouse iPS cells with modified Oct4
Stem Cell Research, 2015 It has been very difficult, if not impossible, to establish mouse induced pluripotent stem cells (iPSCs) from differentiated cells, such as fibroblasts, without leukemia inhibitory factor (LIF).
Hiroyuki Hirai +2 more
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Life, 2021 Leukemia inhibitory factor (LIF), as a member of the interleukin-6 cytokine family, plays a complex role in solid tumors. However, the effect of LIF as a tumor microenvironment factor on plasticity control in breast cancer remains largely unknown.
Nazanin Vaziri +4 more
doaj +1 more source
EMBO Molecular Medicine, 2021 In the course of our studies aiming to discover vascular bed‐specific endothelial cell (EC) mitogens, we identified leukemia inhibitory factor (LIF) as a mitogen for bovine choroidal EC (BCE), although LIF has been mainly characterized as an EC growth ...
Pin Li +11 more
doaj +1 more source
Requirement of Leukemia Inhibitory Factor or Epidermal Growth Factor for Pre-Implantation Embryogenesis via JAK/STAT3 Signaling Pathways. [PDF]
PLoS ONE, 2016 Leukemia inhibitory factor (LIF) plays a key role in the survivability of mouse embryos during pre-implantation. In this study, we verified the role of LIF by detecting gene expression in morula stage embryos through DNA microarray.
En-Hui Cheng +6 more
doaj +1 more source
Bile Acids Are Endogenous Antagonists For the Leukemia inhibitory factor (LIF) receptor
, 2023 The leukemia inhibitory factor (LIF) receptor is involved in various cellular processes, including gastrointestinal cancer growth and invasiveness. Secondary bile acids such as DCA, LCA and its derivatives were found to inhibit LIF/LIFR complex formation,
marchianò, S (via Mendeley Data)
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