Results 41 to 50 of about 129,713 (294)

Leukemia inhibitory factor in rat fetal lung development: expression and functional studies. [PDF]

PLoS ONE, 2012
BACKGROUND: Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are members of the family of the glycoprotein 130 (gp130)-type cytokines. These cytokines share gp130 as a common signal transducer, which explains why they show some functional ...
Cristina Nogueira-Silva, Paulina Piairo, Emanuel Carvalho-Dias, Francisca O Peixoto, Rute S Moura, Jorge Correia-Pinto   +5 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Generation of Sensory Neurons Is Stimulated by Leukemia Inhibitory Factor

, 1991
The processes that regulate the development of peripheral neurons from their precursors in the embryonic neural crest are essentially unknown. In this report, we show that leukemia inhibitory factor stimulates the generation of neurons in cultures of ...
Hilton, DJ, Murphy, M, Reid, K, Bartlett, PF   +3 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

LIF/LIFR Signaling in Gastric Cancer: A Double‐Edged Sword in Tumor Progression and Therapeutic Resistance

Cancer Medicine
Gastric cancer (GC) remains a major cause of cancer‐related mortality worldwide, driven by late‐stage diagnoses and poor survival outcomes. Leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (LIFR) are increasingly recognized as ...
Daniel Park, Kyung‐Il Kim, Yate‐Ching Yuan, Pranati Shah, Hannah Zhong, Yu‐Han Chen, Sharity Ondrejik, Ellen Choi, Sofia Guzman, Vitor Goes, Christiana Crook, Wenqi Wang, Dani Ran Castillo, Daneng Li   +13 more
doaj   +1 more source

Leukemia Inhibitory Factor Promotes Aggressiveness of Chordoma

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2017
Chordomas are rare tumors of the spine and skull base that are locally destructive and resistant to chemotherapy and radiation therapy, with a poor prognosis and limited therapeutic options. Chordoma patients have a long life expectancy with high mortality from the disease.
Gulluoglu, Sukru, Sahin, Mesut, Tuysuz, Emre Can, Yaltirik, Cumhur Kaan, Kuskucu, Aysegul, Ozkan, Ferda, Sahin, Fikrettin, Ture, Ugur, Bayrak, Omer Faruk   +8 more
openaire   +5 more sources

Leukemia Inhibitory Factor Induces Epidermal Hyperplasia in Patients with Amyotrophic Lateral Sclerosis

, 2000
SummaryWe investigated the biochemical and morphologic alteration in skin of amyotrophic lateral sclerosis patients. We found an obvious high expression of leukemia inhibitory factor and distinct epidermal hyperplasia in the skin of amyotrophic lateral ...
Imai, Takashi, Katayama, Hiroyuki, Hu, Jianguo, Nakagawa, Hachiro, Shimizu, Natsue, Ono, Seiitsu   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Establishment of leukemia inhibitory factor (LIF)-independent iPS cells with potentiated Oct4

Stem Cell Research, 2015
Leukemia inhibitory factor (LIF) is widely used to establish and maintain naïve pluripotent stem cells, including mouse embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Hiroyuki Hirai, Meri Firpo, Nobuaki Kikyo   +2 more
doaj   +1 more source