Results 31 to 40 of about 129,713 (294)

Assessment of leukemia inhibitory factor and glycoprotein 130 expression in endometrium and uterine flushing: a possible diagnostic tool for impaired fertility

BMC Women's Health, 2012
Background Uterine receptivity and implantation are complex processes requiring coordinated expression of molecules by zygote and uterus. Our objective was to evaluate the role of the endometrial expression of leukemia inhibitory factor (LIF) and its ...
Tawfeek Manal A, Eid Manal A, Hasan Azza M, Mostafa Manal, El-Serogy Hesham A   +4 more
doaj   +1 more source

Interaction of cytokine LIF with the lipidic matrix of membranes [PDF]

Компьютерные исследования и моделирование, 2010
Integration of LIF protein into the bilayer lipid membrane causes the formation of ion channels. The data on activity of ion channels formed by recombinant protein from mouse and human origin are shown.
Marina Petrovna Borisova, Ludmila M. Mezhevikina, Raushaniya R. Petrova   +2 more
doaj   +1 more source

Possible Role of Leukemia Inhibitory Factor and Inflammatory Cytokines in The Recurrent Spontaneous Abortion: A Case-Control Study [PDF]

International Journal of Fertility and Sterility, 2023
Background: Despite of long-lasting efforts, in more than 50% of cases, the etiology of recurrent spontaneous abortion (RSA) remains unknown. Leukemia inhibitory factor (LIF) has an essential role in the reproductive process, such as modulating ...
Seyed Mohsen Miresmaeili, Farzaneh Fesahat, Negar Kazemi, Hossein Ansariniya, Fateme Zare   +4 more
doaj   +1 more source

The Unsolved Enigmas of Leukemia Inhibitory Factor [PDF]

STEM CELLS, 2003
Leukemia inhibitory factor (LIF) is a polyfunctional glycoprotein cytokine whose inducible production can occur in many, perhaps all, tissues. LIF acts on responding cells by binding to a heterodimeric membrane receptor composed of a low-affinity LIF-specific receptor and the gp130 receptor chain also used as the receptor for interleukin-6, oncostatin ...
openaire   +2 more sources

Downregulation of miR-29c promotes muscle wasting by modulating the activity of leukemia inhibitory factor in lung cancer cachexia

Cancer Cell International, 2021
Background Cancer cachexia is a wasting disorder characterized by significant weight loss, and is attributed to skeletal muscle weakness. In the process of cancer development, microRNAs act as oncogenes or tumor suppressors. Moreover, they are implicated
Kairu Xie, Hairong Xiong, Wen Xiao, Zhiyong Xiong, Wenjun Hu, Jiaxin Ye, Ning Xu, Jian Shi, Changfei Yuan, Zhixian Chen, Daojia Miao, Xiaoping Zhang, Hongmei Yang   +12 more
doaj   +1 more source

Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF

, 2002
Injury to peripheral nerves results in the infiltration of immune cells, which remove axonal- and myelin-derived material. Schwann cells could play a key role in this process by regulating macrophage infiltration.
George K. Tofaris, Kristjan R. Jessen, Rhona Mirsky, Jessen, KR, Patterson, PH, Tofaris, GK, Mirsky, R, Paul H. Patterson   +7 more
core   +1 more source

Osteoblast and Osteoclast Activity Affect Bone Remodeling Upon Regulation by Mechanical Loading-Induced Leukemia Inhibitory Factor Expression in Osteocytes

Frontiers in Molecular Biosciences, 2020
PurposeBone remodeling is affected by mechanical stimulation. Osteocytes are the primary mechanical load-sensing cells in the bone, and can regulate osteoblast and osteoclast activity, thus playing a key role in bone remodeling. Further, bone mass during
Jingke Du, Jiancheng Yang, Zihao He, Zihao He, Junqi Cui, Yiqi Yang, Mingming Xu, Xinhua Qu, Ning Zhao, Mengning Yan, Hanjun Li, Zhifeng Yu   +11 more
doaj   +1 more source

Muscle atrophy reversed by growth factor activation of satellite cells in a mouse muscle atrophy model. [PDF]

PLoS ONE, 2014
Muscular dystrophies comprise a large group of inherited disorders that lead to progressive muscle wasting. We wanted to investigate if targeting satellite cells can enhance muscle regeneration and thus increase muscle mass.
Simon Hauerslev, John Vissing, Thomas O Krag   +2 more
doaj   +1 more source

Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes

Molecular Medicine, 2018
Background The pro-myelinating effects of leukemia inhibitory factor (LIF) and other cytokines of the gp130 family, including oncostatin M (OSM) and ciliary neurotrophic factor (CNTF), have long been known, but controversial results have also been ...
Georgina Gyetvai, Cieron Roe, Lamia Heikal, Pietro Ghezzi, Manuela Mengozzi   +4 more
doaj   +1 more source

Genetic modification and effector functions of natural killer cells in acute myeloid leukemia [PDF]

, 2006
Acute myeloid leukemia (AML) is characterized by a poor long-term outcome in the majority of patients following conventional treatment with chemotherapy.
Siegler, Uwe
core   +1 more source