Results 31 to 40 of about 4,796,691 (248)

Leukemia Inhibitory Factor Induces Epidermal Hyperplasia in Patients with Amyotrophic Lateral Sclerosis [PDF]

, 2000
SummaryWe investigated the biochemical and morphologic alteration in skin of amyotrophic lateral sclerosis patients. We found an obvious high expression of leukemia inhibitory factor and distinct epidermal hyperplasia in the skin of amyotrophic lateral ...
Imai, Takashi, Katayama, Hiroyuki, Hu, Jianguo, Nakagawa, Hachiro, Shimizu, Natsue, Ono, Seiitsu   +5 more
core   +1 more source

Assessment of leukemia inhibitory factor and glycoprotein 130 expression in endometrium and uterine flushing: a possible diagnostic tool for impaired fertility

BMC Women's Health, 2012
Background Uterine receptivity and implantation are complex processes requiring coordinated expression of molecules by zygote and uterus. Our objective was to evaluate the role of the endometrial expression of leukemia inhibitory factor (LIF) and its ...
Tawfeek Manal A, Eid Manal A, Hasan Azza M, Mostafa Manal, El-Serogy Hesham A   +4 more
doaj   +1 more source

Downregulation of miR-29c promotes muscle wasting by modulating the activity of leukemia inhibitory factor in lung cancer cachexia

Cancer Cell International, 2021
Background Cancer cachexia is a wasting disorder characterized by significant weight loss, and is attributed to skeletal muscle weakness. In the process of cancer development, microRNAs act as oncogenes or tumor suppressors. Moreover, they are implicated
Kairu Xie, Hairong Xiong, Wen Xiao, Zhiyong Xiong, Wenjun Hu, Jiaxin Ye, Ning Xu, Jian Shi, Changfei Yuan, Zhixian Chen, Daojia Miao, Xiaoping Zhang, Hongmei Yang   +12 more
doaj   +1 more source

Interaction of cytokine LIF with the lipidic matrix of membranes [PDF]

Компьютерные исследования и моделирование, 2010
Integration of LIF protein into the bilayer lipid membrane causes the formation of ion channels. The data on activity of ion channels formed by recombinant protein from mouse and human origin are shown.
Marina Petrovna Borisova, Ludmila M. Mezhevikina, Raushaniya R. Petrova   +2 more
doaj   +1 more source

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
Pluripotent mouse embryonic stem (ES) cells can be expanded in large numbers in vitro owing to a process of symmetrical self-renewal. Self-renewal entails proliferation with a concomitant suppression of differentiation.
Burdon, Tom, Burdon, T., Smith, A., Savatier, Pierre, Smith, Austin   +4 more
core   +1 more source

Osteoblast and Osteoclast Activity Affect Bone Remodeling Upon Regulation by Mechanical Loading-Induced Leukemia Inhibitory Factor Expression in Osteocytes

Frontiers in Molecular Biosciences, 2020
PurposeBone remodeling is affected by mechanical stimulation. Osteocytes are the primary mechanical load-sensing cells in the bone, and can regulate osteoblast and osteoclast activity, thus playing a key role in bone remodeling. Further, bone mass during
Jingke Du, Jiancheng Yang, Zihao He, Zihao He, Junqi Cui, Yiqi Yang, Mingming Xu, Xinhua Qu, Ning Zhao, Mengning Yan, Hanjun Li, Zhifeng Yu   +11 more
doaj   +1 more source

Muscle atrophy reversed by growth factor activation of satellite cells in a mouse muscle atrophy model. [PDF]

PLoS ONE, 2014
Muscular dystrophies comprise a large group of inherited disorders that lead to progressive muscle wasting. We wanted to investigate if targeting satellite cells can enhance muscle regeneration and thus increase muscle mass.
Simon Hauerslev, John Vissing, Thomas O Krag   +2 more
doaj   +1 more source

Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes

Molecular Medicine, 2018
Background The pro-myelinating effects of leukemia inhibitory factor (LIF) and other cytokines of the gp130 family, including oncostatin M (OSM) and ciliary neurotrophic factor (CNTF), have long been known, but controversial results have also been ...
Georgina Gyetvai, Cieron Roe, Lamia Heikal, Pietro Ghezzi, Manuela Mengozzi   +4 more
doaj   +1 more source

Targeting the MLL complex in acute leukemia [PDF]

, 2014
Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source